Cardiopulmonary bypass with danaparoid sodium and ancrod in heparin-induced thrombocytopenia

被引：10

作者：

Kanagasabay, RR ^{[1
]}

Unsworth-White, MJ ^{[1
]}

Robinson, G ^{[1
]}

Bevan, D ^{[1
]}

Farnsworth, G ^{[1
]}

Haxby, EJ ^{[1
]}

Smith, EEJ ^{[1
]}

机构：

[1] Univ London St Georges Hosp, Dept Cardiothorac Surg, London, England

来源：

ANNALS OF THORACIC SURGERY | 1998年 / 66卷 / 02期

关键词：

D O I：

10.1016/S0003-4975(98)00511-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin is the standard anticoagulant for patients undergoing cardiopulmonary bypass. There are some patients for whom heparin is unsuitable and ancrod (a defibrino-genating enzyme) has been used as an alternative. We present a patient with heparin-induced thrombocytopenia in whom treatment ancrod was ineffective. The addition of danaparoid sodium (a heparinoid) allowed safe cardiopulmonary bypass. We discuss the reasons for this and suggest that the combination of ancrod and danaparoid sodium is a logical one in such cases. (C) 1998 by The Society of Thoracic Surgeons.

引用

页码：567 / 569

页数：3

共 11 条

[1]

ADDONIZIO VP, 1987, SURGERY, V102, P796

[2]

AMIRAL J, 1992, THROMB HAEMOSTASIS, V68, P95

[3]

CHONG BH, 1982, LANCET, V2, P1246

[4]

CHONG BH, 1993, THROMB HAEMOSTASIS, V69, P344

[5] HEPARIN-FREE CARDIOPULMONARY BYPASS - 1ST REPORTED USE OF HEPARINOID (ORG 10172) TO PROVIDE ANTICOAGULATION FOR CARDIOPULMONARY BYPASS [J].

DOHERTY, DC ;

ORTEL, TL ;

DEBRUIJN, N ;

GREENBERG, CS ;

VANTRIGT, P .

ANESTHESIOLOGY, 1990, 73 (03) :562-565

[6] SPECIFIC QUANTIFICATION OF HEPARIN-DEPENDENT ANTIBODIES FOR THE DIAGNOSIS OF HEPARIN-ASSOCIATED THROMBOCYTOPENIA USING AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY [J].

GRUEL, Y ;

RUPIN, A ;

DARNIGE, L ;

MOALICREVERDIAU, P ;

POUMIERGASCHARD, P ;

BINET, C ;

BARDOS, P ;

LEROY, J .

THROMBOSIS RESEARCH, 1991, 62 (05) :377-387

[7] HEPARIN-ASSOCIATED THROMBOCYTOPENIA [J].

KING, DJ ;

KELTON, JG .

ANNALS OF INTERNAL MEDICINE, 1984, 100 (04) :535-540

[8]

MAGNANI HN, 1993, THROMB HAEMOSTASIS, V70, P554

[9]

SCMITT BP, 1993, AM J MED SCI, V305, P208

[10] Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin:platelet factor 4 complexes [J].

Visentin, GP ;

Malik, M ;

Cyganiak, KA ;

Aster, RH .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1996, 128 (04) :376-383

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