Asymmetric catalysis with chiral ferrocene ligands

被引：545

作者：

Dai, LX ^{[1
]}

Tu, T ^{[1
]}

You, SL ^{[1
]}

Deng, WP ^{[1
]}

Hou, XL ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2003年 / 36卷 / 09期

关键词：

2'-SUBSTITUTED 1,1'-P,N-FERROCENE LIGANDS; PLANAR CHIRALITY; ALLYLIC ALKYLATION; P; N-FERROCENE LIGANDS; METAL-COMPLEXES; ENANTIOSELECTIVITY; HYDROGENATION; AMINATION;

D O I：

10.1021/ar020153m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral ferrocene ligands have been widely used in asymmetric catalysis. The advantages of using ferrocene as a scaffold for chiral ligands are described, particularly those regarding planar chirality, rigid bulkiness, and ease of derivatization. The role of planar chirality in 1,2- and 1,1'-disubstituted ferrocene systems is discussed. By using a bulky ferrocene fragment, novel ferrocene ligands were designed, and high enantioselectivity and regioselectivity were achieved in the allylic substitution reaction of monosubstituted allyl substrates. Using the tunable electronic properties of a diphosphine-oxazoline ferrocenyl ligand, the regioselectivity of the intermolecular asymmetric Heck reaction was also examined.

引用

页码：659 / 667

页数：9

共 38 条

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[2]

Bolm C, 2001, ANGEW CHEM INT EDIT, V40, P3285

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