Toxicity of Chemotherapy and Radiation on Female Reproduction

被引：380

作者：

Meirow, Dror ^{[1
]}

Biederman, Hannah ^{[1
]}

Anderson, Richard A. ^{[2
]}

Wallace, W. Hamish B. ^{[2
]}

机构：

[1] Tel Aviv Univ, Chaim Sheba Med Ctr, Fertil Preservat Lab, Div Obstet & Gynecol,IVF Unit, Tel Hashomer, Israel

[2] Univ Edinburgh, Div Reprod & Dev Sci, Edinburgh, Midlothian, Scotland

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2010年 / 53卷 / 04期

基金：

英国医学研究理事会;

关键词：

reproduction; chemotherapy; radiotherapy; ovarian injury; follicles; fertility; BONE-MARROW-TRANSPLANTATION; ANTI-MULLERIAN HORMONE; TOTAL-BODY IRRADIATION; HIGH-DOSE BUSULFAN; CHILDHOOD-CANCER; OVARIAN-FUNCTION; FERTILITY PRESERVATION; PREMENOPAUSAL WOMEN; SURVIVORS; CYCLOPHOSPHAMIDE;

D O I：

10.1097/GRF.0b013e3181f96b54

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

One of the most devastating consequences of cancer treatment in the young female population is ovarian damage, resulting in diminished fertility potential. The extent of damage is related to age, chemotherapeutic regimen, and dose of pelvic radiation received. It is crucial that physicians know the impact each of these factors has on future fertility to advice patients on fertility preservation options. Anticancer drugs injure the female reproductive system through ovarian follicular and stromal damage. Although the exact mechanisms of damage remain unclear, it is essential to better understand these mechanisms to develop methods to diminish ovarian injury.

引用

页码：727 / 739

页数：13

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