Signal-to-noise analysis for 3D luminescence imaging of hypoxia in deep tissues

被引：0

作者：

Gurjar, Rajan ^{[1
]}

Seetamraju, Madhavi ^{[1
]}

Wolf, David ^{[1
]}

机构：

[1] Radiat Monitoring Devices Inc, Watertown, MA 02472 USA

来源：

ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VIII | 2010年 / 7555卷

关键词：

Luminescence; Hypoxia; Signal-to-Noise; Point-Spread-Function; PHOSPHORESCENCE LIFETIME; MEASURING OXYGEN;

D O I：

10.1117/12.840736

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We provide a detailed signal-to-noise analysis for 3D imaging of luminescence from a biomarker to detect hypoxic tumors in deep tissue. Preliminary studies on phantom tissues with inclusions and having homogeneous scattering and absorption coefficient of mu(s)' similar to 15-20 cm(-1) and mu(a) similar to 2 cm(-1) respectively, are reported as a function of oxygen tension, luminophore concentration, and tissue depth. The technique's sensitivity in terms of determination of spatial resolution is discussed.

引用

页数：6

共 13 条

[1] Tomographic imaging of oxygen by phosphorescence lifetime [J].

Apreleva, Sovia V. ;

Wilson, David F. ;

Vinogradov, Sergei A. .

APPLIED OPTICS, 2006, 45 (33) :8547-8559

[2] Feasibility of diffuse optical imaging with long-lived luminescent probes [J].

Apreleva, SV ;

Wilson, DE ;

Vinogradov, SA .

OPTICS LETTERS, 2006, 31 (08) :1082-1084

[3] Development of fluorescent materials for diffuse fluorescence tomography standards and phantoms [J].

Baeten, John ;

Niedre, Mark ;

Dunham, Joshua ;

Ntziachristos, Vasilis .

OPTICS EXPRESS, 2007, 15 (14) :8681-8694

[4] Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels [J].

Christian, S ;

Pilch, J ;

Akerman, ME ;

Porkka, K ;

Laakkonen, P ;

Ruoslahti, E .

JOURNAL OF CELL BIOLOGY, 2003, 163 (04) :871-878

[5] Oxyphor R2 and G2: phosphors for measuring oxygen by oxygen-dependent quenching of phosphorescence [J].

Dunphy, I ;

Vinogradov, SA ;

Wilson, DF .

ANALYTICAL BIOCHEMISTRY, 2002, 310 (02) :191-198

[6] Synthesis and luminescence of soluble meso-unsubstituted tetrabenzo- and tetranaphtho[2,3]porphyrins [J].

Finikova, OS ;

Cheprakov, AV ;

Vinogradov, SA .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (23) :9562-9572

[7]

GURJAR R, 2009, IEEE P INT S BIOM IM

[8] Brain cancer diagnosis and therapy with nanoplatforms [J].

Koo, Yong-Eun Lee ;

Reddy, G. Ramachandra ;

Bhojani, Mahaveer ;

Schneider, Randy ;

Philbert, Martin A. ;

Rehemtulla, Alnawaz ;

Ross, Brian D. ;

Kopelman, Raoul .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1556-1577

[9]

Mandel J., 2012, The Statistical Analysis of Experimental Data

[10] Vascular targeted nanoparticles for imaging and treatment of brain tumors [J].

Reddy, G. Ramachandra ;

Bhojani, Mahaveer S. ;

McConville, Patrick ;

Moody, Jonathan ;

Moffat, Bradford A. ;

Hall, Daniel E. ;

Kim, Gwangseong ;

Koo, Yong-Eun L. ;

Woolliscroft, Michael J. ;

Sugai, James V. ;

Johnson, Timothy D. ;

Philbert, Martin A. ;

Kopelman, Raoul ;

Rehemtulla, Alnawaz ;

Ross, Brian D. .

CLINICAL CANCER RESEARCH, 2006, 12 (22) :6677-6686

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