Ferric(III) Nitrate: An Efficient Catalyst for the Regioselective Friedel-Crafts Reactions of Indoles and tert-Enamides in Water

被引：23

作者：

Jiang, Ran ^{[1
]}

Wu, Xiao-Jin ^{[1
]}

Zhu, Xu ^{[1
]}

Xu, Xiao-Ping ^{[1
]}

Ji, Shun-Jun ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 31期

基金：

中国国家自然科学基金;

关键词：

Iron; Alkylation; Nitrogen heterocycles; Water chemistry; Green chemistry; CHIRAL BRONSTED ACID; 1,3-DICARBONYL COMPOUNDS; ORGANIC-SYNTHESIS; MICHAEL ADDITION; FACILE SYNTHESIS; ALKYLATION; HETEROCYCLES; BENZENE; HYDROAMINATION; BENZYLATION;

D O I：

10.1002/ejoc.201000994

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ferric nitrate catalyzed Friedel-Crafts reactions of various indoles and tertiary enamides, which proceed in water at room temperature, are demonstrated for an efficient, atom-economical and environmentally friendly route to produce indole derivatives under mild conditions. Based on experimental data and mechanistic studies, the iron(III) ion was found to activate the electron-rich C=C bond with collaboration of the carbonyl group in the catalytic process.

引用

页码：5946 / 5950

页数：5

共 16 条

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[9] Hafnium-Doped Mesoporous Silica as Efficient Lewis Acidic Catalyst for Friedel-Crafts Alkylation Reactions
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[10] Ultrasound assisted microencapsulation of zinc triflate in polyethersulfone as an efficient regioselective catalyst for Friedel-Crafts acylation reaction
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