Genome-wide association studies of 14 agronomic traits in rice landraces

被引：1563

作者：

Huang, Xuehui ^{[1
,2
]}

Wei, Xinghua ^{[3
]}

Sang, Tao ^{[5
]}

Zhao, Qiang ^{[1
,2
]}

Feng, Qi ^{[1
]}

Zhao, Yan ^{[1
]}

Li, Canyang ^{[1
]}

Zhu, Chuanrang ^{[1
]}

Lu, Tingting ^{[1
]}

Zhang, Zhiwu ^{[4
]}

Li, Meng ^{[4
,6
]}

Fan, Danlin ^{[1
]}

Guo, Yunli ^{[1
]}

Wang, Ahong ^{[1
]}

Wang, Lu ^{[1
]}

Deng, Liuwei ^{[1
]}

Li, Wenjun ^{[1
]}

Lu, Yiqi ^{[1
]}

Weng, Qijun ^{[1
]}

Liu, Kunyan ^{[1
]}

Huang, Tao ^{[1
]}

Zhou, Taoying ^{[1
]}

Jing, Yufeng ^{[1
]}

Li, Wei ^{[1
]}

Lin, Zhang ^{[1
]}

Buckler, Edward S. ^{[4
,7
]}

Qian, Qian ^{[3
]}

Zhang, Qi-Fa ^{[8
]}

Li, Jiayang ^{[9
]}

Han, Bin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Natl Ctr Gene Res, Shanghai, Peoples R China

[2] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing, Peoples R China

[3] Chinese Acad Agr Sci, China Natl Rice Res Inst, State Key Lab Rice Biol, Hangzhou, Zhejiang, Peoples R China

[4] Cornell Univ, Inst Genom Divers, Ithaca, NY USA

[5] Michigan State Univ, Dept Plant Biol, E Lansing, MI 48824 USA

[6] Nanjing Agr Univ, Coll Agr, State Key Lab Crop Genet & Germplasm Enhancement, Natl Ctr Soybean Improvement, Nanjing, Peoples R China

[7] USDA ARS, Ithaca, NY 14853 USA

[8] Huazhong Agr Univ, Natl Ctr Plant Gene Res Wuhan, Natl Key Lab Crop Genet Improvement, Wuhan, Peoples R China

[9] Chinese Acad Sci, Natl Ctr Plant Gene Res, Inst Genet & Dev Biol, Beijing, Peoples R China

来源：

NATURE GENETICS | 2010年 / 42卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ARABIDOPSIS-THALIANA; HAPLOTYPE MAP; CULTIVATED RICE; ORYZA-SATIVA; MAIZE; GENE; DOMESTICATION; PHENOTYPES; VARIETIES; SEQUENCE;

D O I：

10.1038/ng.695

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified similar to 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained similar to 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.

引用

页码：961 / U76

页数：9

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