Spiroarthrinols a and B, two novel meroterpenoids isolated from the spongederived fungus Arthrinium sp

被引：35

作者：

Elissawy, Ahmed M. ^{[1
]}

Ebada, Sherif S. ^{[1
]}

Ashour, Mohamed L. ^{[1
]}

Ozkaya, Ferhat C. ^{[2
]}

Ebrahim, Weaam ^{[3
,4
]}

Singab, AbelNasser B. ^{[1
]}

Proksch, Peter ^{[4
]}

机构：

[1] Ain Shams Univ, Dept Pharmacognosy, Fac Pharm, Org African Unity St 1, Cairo 11566, Egypt

[2] Izmir Katip Celebi Univ, Dept Aquaculture, Fac Fisheries, TR-35100 Izmir, Bornova, Turkey

[3] Mansoura Univ, Dept Pharmacognosy, Fac Pharm, Mansoura 35516, Egypt

[4] Heinrich Heine Univ, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 20卷

关键词：

Marine derived fungi; Arthrinium; Spiro compounds; Cytotoxicity; POLYCYCLIC SPIRO LIGNANS; ENDOPHYTIC FUNGUS; BIOACTIVE METABOLITES; MARINE; CONSTITUENTS; GRISEOFULVIN; DERIVATIVES; APOPTOSIS; CANCER; ACID;

D O I：

10.1016/j.phytol.2017.05.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the sponge derived fungus Arthrinium sp. following fermentation on solid rice medium led to the isolation of two new meroterpenoidal alcohols spiroarthrinols A (1) and B (2) together with eighteen known compounds (3-20). The structures and relative configuration of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. In addition, a plausible biosynthetic pathway for the new compounds spiroarthrinols A (1) and B (2) was postulated encompassing a mixed polyketide/terpenoid pathway. When assessed for their antiproliferative activity against Caco-2 cell lines, none of the isolated compounds showed significant cytotoxicity.

引用

页码：246 / 251

页数：6

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