Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optical

被引：1
|
作者：
Chen, Tingjun [1 ]
Li, Zhaohui [1 ]
Jiang, Zhaocai [1 ,4 ]
Liu, Zihao [1 ,5 ]
Xu, Quangang [3 ]
Huang, Dehui [3 ]
Lin, Qing [2 ]
Wei, Shihui [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dep Neuroophthalmol, Beijing, Peoples R China
[2] Univ Texas Arlington, Coll Sci, Dept Psychol, Arlington, TX 76019 USA
[3] Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing, Peoples R China
[4] LongFu Hosp, Dept Ophthalmol, Being, Peoples R China
[5] Dongzhimen Hosp, Dept Ophthalmol, Beijing, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 279卷
基金：
美国国家卫生研究院;
关键词：
Platelet-derived growth factor; CXC-motif ligand 12; CXC-motif ligand 14; Idiopathic demyelinating optic neuritis; Neuromyelitis optica; Enzyme linked immunosorbent assay; Biomarkers; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; OLIGODENDROCYTE PROGENITORS; DIFFERENTIAL-DIAGNOSIS; SYNAPTIC PLASTICITY; TRANSVERSE MYELITIS; GROWTH-FACTORS; EXPRESSION; CELLS; PROLIFERATION;
D O I：
10.1016/bjneuroim.2014.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The CXC chemokines (CXC-motif ligand 12 and CXC-motif ligand 14) and platelet-derived growth factor are suggested to modulate remyelination in the course of many demyelinating diseases. The present study compared the difference in the brain levels of these chemokines between patients with idiopathic demyelinating optic neuritis (IDON) and neuromyelitis optica (NMO) by measuring their concentrations in the cerebrospinal fluid using an enzyme linked immunosorbent assay. Our data indicate that the prognosis of neuritis depends on the remyelinating process that is impaired due to decreased chemokines. The much lower levels of chemokines would specifically indicate the severe neuritis, such as NMO. (C) 2014 Elsevier B.V. All rights reserved.
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页码：1 / 6
页数：6
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