An investigation of thermally induced collagen structural transitions by second harmonic generation microscopy

被引:0
|
作者
Sun, Y [1 ]
Lin, SJ [1 ]
Hsiao, CY [1 ]
Lo, W [1 ]
Jee, SH [1 ]
Dong, CY [1 ]
机构
[1] Natl Taiwan Univ, Dept Phys, Taipei 10764, Taiwan
关键词
D O I
10.1109/APBP.2004.1412339
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this work, the thermal disruption of type I collagen is investigated using second harmonic generation (SHG) microscopy. We investigated the effects of second harmonic generation images and intensity of rat tail tendon in the temperature range from 25 to 60 degrees C. We found a structural transition at 57 degrees C where a drop in second harmonic intensity is correlated to a disorganization of the collagen fibers. Our results suggest that SHG microscopy is an effective technique to monitor thermally induced collagen structural changes for biomedical applications.
引用
收藏
页码:177 / 178
页数:2
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