Gut Microbiota and Atherosclerosis-Focusing on the Plaque Stability

被引：55

作者：

Shen, Xinyi ^{[1
]}

Li, Lihua ^{[2
]}

Sun, Zhen ^{[1
]}

Zang, Guangyao ^{[1
]}

Zhang, Lili ^{[1
]}

Shao, Chen ^{[1
]}

Wang, Zhongqun ^{[1
]}

机构：

[1] Jiangsu Univ, Dept Cardiol, Affiliated Hosp, Zhenjiang, Jiangsu, Peoples R China

[2] Jiangsu Univ, Affiliated Hosp, Dept Pathol, Zhenjiang, Jiangsu, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

atherosclerosis; metabolites; therapies; plaque stability; gut microbiota; CORONARY-ARTERY-DISEASE; TRIMETHYLAMINE-N-OXIDE; LIPOPOLYSACCHARIDE-BINDING PROTEIN; HUMAN COLONIC MICROBIOTA; CHAIN FATTY-ACIDS; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; FECAL MICROBIOTA; MUCUS BARRIER;

D O I：

10.3389/fcvm.2021.668532

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.

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