Gut Microbiota and Atherosclerosis-Focusing on the Plaque Stability

被引：43
作者：
Shen, Xinyi [1 ]
Li, Lihua [2 ]
Sun, Zhen [1 ]
Zang, Guangyao [1 ]
Zhang, Lili [1 ]
Shao, Chen [1 ]
Wang, Zhongqun [1 ]
机构：
[1] Jiangsu Univ, Dept Cardiol, Affiliated Hosp, Zhenjiang, Jiangsu, Peoples R China
[2] Jiangsu Univ, Affiliated Hosp, Dept Pathol, Zhenjiang, Jiangsu, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
基金：
中国国家自然科学基金;
关键词：
atherosclerosis; metabolites; therapies; plaque stability; gut microbiota; CORONARY-ARTERY-DISEASE; TRIMETHYLAMINE-N-OXIDE; LIPOPOLYSACCHARIDE-BINDING PROTEIN; HUMAN COLONIC MICROBIOTA; CHAIN FATTY-ACIDS; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; FECAL MICROBIOTA; MUCUS BARRIER;
D O I：
10.3389/fcvm.2021.668532
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.
引用
收藏
页数：15
相关论文
共 204 条
  • [21] Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque
    Carnevale, Roberto
    Nocella, Cristina
    Petrozza, Vincenzo
    Cammisotto, Vittoria
    Pacini, Luca
    Sorrentino, Veronica
    Martinelli, Ombretta
    Irace, Luigi
    Sciarretta, Sebastiano
    Frati, Giacomo
    Pastori, Daniele
    Violi, Francesco
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [22] Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
    Casas, Rosa
    Urpi-Sarda, Mireia
    Sacanella, Emilio
    Arranz, Sara
    Corella, Dolores
    Castaner, Olga
    Lamuela-Raventos, Rosa-Maria
    Salas-Salvado, Jordi
    Lapetra, Jose
    Portillo, Maria P.
    Estruch, Ramon
    [J]. MEDIATORS OF INFLAMMATION, 2017, 2017
  • [23] The Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
    Casas, Rosa
    Sacanella, Emilio
    Urpi-Sarda, Mireia
    Chiva-Blanch, Gemma
    Ros, Emilio
    Martinez-Gonzalez, Miguel-Angel
    Covas, Maria-Isabel
    Ma Lamuela-Raventos, Rosa
    Salas-Salvado, Jordi
    Fiol, Miquel
    Aros, Fernando
    Estruch, Ramon
    [J]. PLOS ONE, 2014, 9 (06):
  • [24] Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE-/- mice
    Chan, Yee Kwan
    El-Nezami, Hani
    Chen, Yan
    Kinnunen, Kristiina
    Kirjavainen, Pirkka V.
    [J]. AMB EXPRESS, 2016, 6
  • [25] Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins
    Chao, Chia-Ter
    Lin, Shih-Hua
    [J]. TOXINS, 2020, 12 (12)
  • [26] Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway
    Chen, Ming-liang
    Zhu, Xiao-hui
    Ran, Li
    Lang, He-dong
    Yi, Long
    Mi, Man-tian
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (09):
  • [27] Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis
    Chen, Poshen B.
    Black, Audrey S.
    Sobel, Adam L.
    Zhao, Yannan
    Mukherjee, Purba
    Molparia, Bhuvan
    Moore, Nina E.
    Aleman Muench, German R.
    Wu, Jiejun
    Chen, Weixuan
    Pinto, Antonio F. M.
    Maryanoff, Bruce E.
    Saghatelian, Alan
    Soroosh, Pejman
    Torkamani, Ali
    Leman, Luke J.
    Ghadiri, M. Reza
    [J]. NATURE BIOTECHNOLOGY, 2020, 38 (11) : 1288 - +
  • [28] Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota
    Chen, Runzhi
    Xu, Ying
    Wu, Peng
    Zhou, Hao
    Lasanajak, Yi
    Fang, Yingying
    Tang, Lan
    Ye, Ling
    Li, Xing
    Cai, Zheng
    Zhao, Jie
    [J]. PHARMACOLOGICAL RESEARCH, 2019, 148
  • [29] Short-chain fatty acid, acylation and cardiovascular diseases
    Chen, Xiao-Feng
    Chen, Xiangqi
    Tang, Xiaoqiang
    [J]. CLINICAL SCIENCE, 2020, 134 (06) : 657 - 676
  • [30] From the Mediterranean Diet to the Microbiome
    Childs, Caroline E.
    [J]. JOURNAL OF NUTRITION, 2018, 148 (06) : 819 - 820
12345678910