Gut Microbiota and Atherosclerosis-Focusing on the Plaque Stability

被引：43
作者：
Shen, Xinyi [1 ]
Li, Lihua [2 ]
Sun, Zhen [1 ]
Zang, Guangyao [1 ]
Zhang, Lili [1 ]
Shao, Chen [1 ]
Wang, Zhongqun [1 ]
机构：
[1] Jiangsu Univ, Dept Cardiol, Affiliated Hosp, Zhenjiang, Jiangsu, Peoples R China
[2] Jiangsu Univ, Affiliated Hosp, Dept Pathol, Zhenjiang, Jiangsu, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
基金：
中国国家自然科学基金;
关键词：
atherosclerosis; metabolites; therapies; plaque stability; gut microbiota; CORONARY-ARTERY-DISEASE; TRIMETHYLAMINE-N-OXIDE; LIPOPOLYSACCHARIDE-BINDING PROTEIN; HUMAN COLONIC MICROBIOTA; CHAIN FATTY-ACIDS; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; FECAL MICROBIOTA; MUCUS BARRIER;
D O I：
10.3389/fcvm.2021.668532
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.
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页数：15
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共 204 条
  • [1] Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox
    Aboonabi, Anahita
    Singh, Indu
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2015, 72 : 30 - 36
  • [2] Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells
    Aguilar, Edenil C.
    dos Santos, Lana Claudinez
    Leonel, Alda J.
    de Oliveira, Jamil Silvano
    Santos, Elandia Aparecida
    Navia-Pelaez, Juliana M.
    da Silva, Josiane Fernandes
    Mendes, Barbara Pinheiro
    Capettini, Luciano S. A.
    Teixeira, Lilian G.
    Lemos, Virginia S.
    Alvarez-Leite, Jacqueline I.
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2016, 34 : 99 - 105
  • [3] A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis
    Ahmadi, Shokouh
    Wang, Shaohua
    Nagpal, Ravinder
    Wang, Bo
    Jain, Shalini
    Razazan, Atefeh
    Mishra, Sidharth P.
    Zhu, Xuewei
    Wang, Zhan
    Kavanagh, Kylie
    Yadav, Hariom
    [J]. JCI INSIGHT, 2020, 5 (09)
  • [4] Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications
    Backhed, Fredrik
    Fraser, Claire M.
    Ringel, Yehuda
    Sanders, Mary Ellen
    Sartor, R. Balfour
    Sherman, Philip M.
    Versalovic, James
    Young, Vincent
    Finlay, B. Brett
    [J]. CELL HOST & MICROBE, 2012, 12 (05) : 611 - 622
  • [5] NF-κB, Inflammation, and Metabolic Disease
    Baker, Rebecca G.
    Hayden, Matthew S.
    Ghosh, Sankar
    [J]. CELL METABOLISM, 2011, 13 (01) : 11 - 22
  • [6] Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis
    Baragetti, Andrea
    Severgnini, Marco
    Olmastroni, Elena
    Dioguardi, Carola Conca
    Mattavelli, Elisa
    Angius, Andrea
    Rotta, Luca
    Cibella, Javier
    Caredda, Giada
    Consolandi, Clarissa
    Grigore, Liliana
    Pellegatta, Fabio
    Giavarini, Flavio
    Caruso, Donatella
    Norata, Giuseppe Danilo
    Catapano, Alberico Luigi
    Peano, Clelia
    [J]. NUTRIENTS, 2021, 13 (02) : 1 - 19
  • [7] Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
    Barcena, Clea
    Valdes-Mas, Rafael
    Mayoral, Pablo
    Garabaya, Cecilia
    Durand, Sylvere
    Rodriguez, Francisco
    Teresa Fernandez-Garcia, Maria
    Salazar, Nuria
    Nogacka, Alicja M.
    Garatachea, Nuria
    Bossut, Noelie
    Aprahamian, Fanny
    Lucia, Alejandro
    Kroemer, Guido
    Freije, Jose M. P.
    Quiros, Pedro M.
    Lopez-Otin, Carlos
    [J]. NATURE MEDICINE, 2019, 25 (08) : 1234 - +
  • [8] Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage
    Bartolomaeus, Hendrik
    Balogh, Andras
    Yakoub, Mina
    Homann, Susanne
    Marko, Lajos
    Hoeges, Sascha
    Tsvetkov, Dmitry
    Krannich, Alexander
    Wundersitz, Sebastian
    Avery, Ellen G.
    Haase, Nadine
    Kraeker, Kristin
    Hering, Lydia
    Maase, Martina
    Kusche-Vihrog, Kristina
    Grandoch, Maria
    Fielitz, Jens
    Kempa, Stefan
    Gollasch, Maik
    Zhumadilov, Zhaxybay
    Kozhakhmetov, Samat
    Kushugulova, Almagul
    Eckardt, Kai-Uwe
    Dechend, Ralf
    Rump, Lars Christian
    Forslund, Sofia K.
    Mueller, Dominik N.
    Stegbauer, Johannes
    Wilck, Nicola
    [J]. CIRCULATION, 2019, 139 (11) : 1407 - 1421
  • [9] Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
    Bennett, Brian J.
    Vallim, Thomas Q. de Aguiar
    Wang, Zeneng
    Shih, Diana M.
    Meng, Yonghong
    Gregory, Jill
    Allayee, Hooman
    Lee, Richard
    Graham, Mark
    Crooke, Rosanne
    Edwards, Peter A.
    Hazen, Stanley L.
    Lusis, Aldons J.
    [J]. CELL METABOLISM, 2013, 17 (01) : 49 - 60
  • [10] A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity
    Beserra, Bruna T. S.
    Fernandes, Ricardo
    do Rosario, Vinicius A.
    Mocellin, Michel C.
    Kuntz, Marilyn G. F.
    Trindade, Erasmo B. S. M.
    [J]. CLINICAL NUTRITION, 2015, 34 (05) : 845 - 858
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