Immunogenic properties of peptides mimicking a HIV-1 gp41 epitope recognized by virus-neutralizing antibodies 2F5

被引：2
|
作者：
Tumanova, OY [1 ]
Kuvshinov, VN
Orlovskaya, IA
Pronyaeva, TR
Pokrovskii, AG
Il'ichev, AA
Sandakhchiev, LS
机构：
[1] Vector State Res Ctr Virol & Biotechnol, Inst Bioengn, Koltsov 630559, Novosibirsk Reg, Russia
[2] Russian Acad Med Sci, Siberian Div, Inst Clin Immunol, Novosibirsk 630091, Russia
[3] Vector State Res Ctr Virol & Biotechnol, Inst Mol Biol, Koltsov 630559, Novosibirsk Reg, Russia
来源：
MOLECULAR BIOLOGY | 2003年 / 37卷 / 03期
关键词：
HIV-1; neutralizing epitope of gp41; mimicking peptides; phage display; immunogenicity; neutralizing activity;
D O I：
10.1023/A:1024259915720
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phage display was used to obtain peptides mimicking a HIV-1 gp41 conserved epitope recognized by virus-neutralizing monoclonal antibodies (mAb) 2F5. Rabbits and mice were immunized with the peptides exposed on the surface of filamentous bacteriophages. Antibodies to gp41 were detected in the sera of immunized animals. The virus-neutralizing activity of the sera was examined.
引用
收藏
页码：473 / 476
页数：4
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