Adherence to the Mediterranean Diet in Relation to All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

被引：136

作者：

Soltani, Sepideh ^{[1
]}

Jayedi, Ahmad ^{[2
]}

Shab-Bidar, Sakineh ^{[3
]}

Becerra-Tomas, Nerea ^{[4
,5
]}

Salas-Salvado, Jordi ^{[4
,5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, Tehran, Iran

[2] Semnan Univ Med Sci, Food Salt Safety Res Ctr, Semnan, Iran

[3] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran

[4] Rovira & Virgili Univ, Univ Hosp St Joan de Reus, Dept Biochem & Biotechnol,Fac Med & Hlth Sci, Inst Invest Sanitaria Pere Virgili,Human Nutr Uni, Reus, Spain

[5] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain

来源：

ADVANCES IN NUTRITION | 2019年 / 10卷 / 06期

关键词：

Mediterranean diet; mortality; meta-analysis; prospective cohort studies; dose-response; LIFE-STYLE FACTORS; CARDIOVASCULAR-DISEASE; PREMATURE MORTALITY; QUALITY INDEXES; RISK; SURVIVAL; PATTERNS; WOMEN; SCORE; MEN;

D O I：

10.1093/advances/nmz041

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

A previous meta-analysis provided convincing evidence for an inverse association between adherence to a Mediterranean diet (MedDiet) and the risk of all-cause mortality. Since then, 19 prospective studies have been published. We updated the evidence from these prospective studies and conducted a dose-response meta-analysis to test the linear and potential nonlinear dose-response associations between adherence to a MedDiet and the risk of all-cause mortality. The PubMed, Scopus, ISI Web of Knowledge, and Embase bibliographic databases were systematically searched up to August 24, 2018. Summary HRs were estimated with the use of a random-effects meta-analysis to assess the association between a 2-point increment in MedDiet adherence and the risk of all-cause mortality. Sensitivity and subgroup analyses were performed and potential publication bias was tested. Twenty-nine prospective studies with 1,676,901 participants and 221,603 cases of all-cause mortality were included in the final analysis. The pooled HR of all-cause mortality was 0.90 (95% CI: 0.89, 0.91; I-2 = 81.1%) for a 2-point increment in adherence to a MedDiet. Subgroup analyses showed that a significant inverse association was stronger in participants who lived in the Mediterranean region compared with non-Mediterranean areas (HRs: 0.82 compared with 0.92, respectively), and in studies that used the Panagiotakos MedDiet score. A nonlinear dose-response meta-analysis indicated that the risk of all-cause mortality linearly decreased with the increase in adherence to a MedDiet. The robustness of findings was confirmed in the sensitivity analyses. In conclusion, low-quality evidence from prospective cohort studies suggests an inverse association between adherence to a MedDiet and the risk of all-cause mortality, especially in Mediterranean regions. An inverse linear dose-response relation was also observed between adherence to a MedDiet and the risk of all-cause mortality.

引用

页码：1029 / 1039

页数：11

共 66 条

[31] The Mediterranean Diet Is Associated with a Reduction in Premature Mortality among Middle-Aged Adults [J].