Central Amygdala Somatostatin Neurons Gate Passive and Active Defensive Behaviors

被引:113
|
作者
Yu, Kai [1 ]
da Silva, Pedro Garcia [1 ,2 ]
Albeanu, Dinu F. [1 ]
Li, Bo [1 ]
机构
[1] Cold Spring Harbor Lab, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA
[2] Champalimaud Ctr Unknown, Champalimaud Neurosci Program, P-1400038 Lisbon, Portugal
来源
JOURNAL OF NEUROSCIENCE | 2016年 / 36卷 / 24期
基金
美国国家卫生研究院;
关键词
active avoidance; central amygdala; fear; fiber-optic photometry; optogenetics; somatostatin neurons; CONDITIONED FEAR; LATERAL AMYGDALA; ACTIVATION; CIRCUITS; MEMORY; SUPPRESSION; RESPONSES; NUCLEUS; LINES; RAT;
D O I
10.1523/JNEUROSCI.4419-15.2016
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The central amygdala (CeA) has a key role in learning and expression of defensive responses. Recent studies indicate that somatostatin-expressing (SOM+) neurons in the lateral division of the CeA (CeL) are essential for the acquisition and recall of conditioned freezing behavior, which has been used as an index of defensive response in laboratory animals during Pavlovian fear conditioning. However, how exactly these neurons participate in fear conditioning and whether they contribute to the generation of defensive responses other than freezing remain unknown. Here, using fiber-optic photometry combined with optogenetic and molecular techniques in behaving mice, we show that SOM+ CeL neurons are activated by threat-predicting sensory cues after fear conditioning and that activation of these neurons suppresses ongoing actions and converts an active defensive behavior to a passive response. Furthermore, inhibition of these neurons using optogenetic or molecular methods promotes active defensive behaviors. Our results provide the first in vivo evidence that SOM+ neurons represent a CeL population that acquires learning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important role of these neurons in gating passive versus active defensive behaviors in animals confronted with threat.
引用
收藏
页码:6488 / 6496
页数:9
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