Response of Blood Parameters to CPAP Treatment in Patients with Obstructive Sleep Apnea

Introduction: Many studies have evaluated the relationship between the NLR and PLR in patients with obstructive sleep apnea (OSA), and have shown that they are related to inflammation. We evaluated whether 3 months of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSA without any comorbidities would affect the NLR and PLR values. Methods: Full blood count parameters were evaluated before and after 3 months of CPAP treatment in patients with a diagnosis of moderate to severe OSA without any comorbidities. Results: Twenty-nine patients (18 [62.1%J males) were enrolled. The mean body mass index (BMI) was 34.85 +/- 5.75 kg/m2, the apnea-hypopnea index score was 49.85 +/- 27.42, and CPAP was 934 +/- 1.77. No significant change in BMI was observed after the third month of treatment. Although the Epworth Sleepiness Scale (ESS) score decreased significantly (p=0.000), no changes were observed in the NLR, PLR, or C-reactive protein level (p>0.05). Mean platelet volume and red blood cell distribution width changed significantly after treatment (p=0.01; p<0.001). Conclusions: The NLR and PLR did not change after CPAP treatment in patients with moderate to severe OSA without any comorbidities.