Opinion - The role of apoptosis in cancer development and treatment response

被引：745

作者：

Brown, JM ^{[1
]}

Attardi, LD ^{[1
]}

机构：

[1] Stanford Univ, Dept Radiat Oncol, Div Radiat & Canc Biol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrc1560

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.

引用

页码：231 / 237

页数：8

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