The role of NF-κB/IκB proteins in cancer:: implications for novel treatment strategies

被引：108

作者：

Schwartz, SA ^{[1
]}

Hernandez, A ^{[1
]}

Evers, BM ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Surg, Galveston, TX 77555 USA

来源：

SURGICAL ONCOLOGY-OXFORD | 1999年 / 8卷 / 03期

关键词：

NF-kappa B; apoptosis; transcription factors; cancer biology;

D O I：

10.1016/S0960-7404(00)00012-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The nuclear factor-kappaB (NF-kappaB) family of transcription factors are involved in multiple cellular processes, including cytokine gene expression, cellular adhesion, cell cycle activation, apoptosis and oncogenesis. Constitutive activation of NF-kappaB has been described in a number of solid tumors and this activation appears to affect cancer cell survival. Inhibition of NF-kappaB has been shown to enhance the sensitivity of some cancer cell lines to antineoplastic- or radiation-induced apoptosis. Furthermore, suppression of NF-kappaB results in attenuation of cancer cachexia in a mouse tumor model. Studies are underway to further delineate the role of NF-kappaB in cancer cell survival, growth and resistance to standard chemotherapy and radiation regimens. Moreover, the effects of novel therapeutic agents which specifically target NF-kappaB proteins are currently being assessed in experimental models of cancer cell growth both in vitro and in vivo. In this review, we discuss the possible involvement of NF-kappaB in the growth of various solid tumors and potential future treatment strategies based on NF-kappaB inhibition. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：143 / 153

页数：11

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