Carbonyl reductase

被引：202
作者：
Forrest, GL [1 ]
Gonzalez, B [1 ]
机构：
[1] City Hope Natl Med Ctr, Beckman Res Inst, Dept Biol, Duarte, CA 91010 USA
来源：
CHEMICO-BIOLOGICAL INTERACTIONS | 2000年 / 129卷 / 1-2期
关键词：
carbonyl reductase; transgenic mice; cardiotoxicity; xenobiotic metabolism;
D O I：
10.1016/S0009-2797(00)00196-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carbonyl reductase (secondary-alcohol:NADP(+) oxidoreductase, EC 1.1.1.184) belongs to the family of short chain dehydrogenases/reductases (SDR). Carbonyl reductases (CBRs) are NADPH-dependent, mostly monomeric, cytosolic enzymes with broad substrate specificity for many endogenous and xenobiotic carbonyl compounds. They catalyze the reduction of endogenous prostaglandins, steroids, and other aliphatic aldehydes and ketones. They also reduce a wide variety of xenobiotic quinones derived from polycyclic aromatic hydrocarbons. CBR reduces the anthracycline anticancer drugs, daunorubicin(dn) and doxorubicin (dox) to their C-13 hydroxy metabolites, changing the pharmacological properties of these drugs. Emerging data on CBRs over the last several years is generating new insights on the potential involvement of CBRs in a variety of cellular and molecular reactions associated with drug metabolism, detoxication, drug resistance, mutagenesis, and carcinogenesis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：21 / 40
页数：20
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