Parallel Solution Phase Synthesis of 3,6,7-4(3H)-Quinazolinones and Evaluation of Their Antitumor Activities against Human Cancer

被引：27
|
作者：
Wu, Hao
Xie, Xilei
Liu, Gang [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 03期
基金：
中国国家自然科学基金;
关键词：
NITRO-COMPOUNDS; PRIVILEGED STRUCTURES; INHIBITORS; REDUCTION; POTENT; AGENTS; QUINAZOLINES; DISCOVERY; ANALOGS; FACILE;
D O I：
10.1021/cc900173s
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against a panel of human tumor cell lines, which pointed out preliminary structure-activity relationships.
引用
收藏
页码：346 / 355
页数：10
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