Parallel Solution Phase Synthesis of 3,6,7-4(3H)-Quinazolinones and Evaluation of Their Antitumor Activities against Human Cancer

被引：27

作者：

Wu, Hao

Xie, Xilei

Liu, Gang ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 03期

基金：

中国国家自然科学基金;

关键词：

NITRO-COMPOUNDS; PRIVILEGED STRUCTURES; INHIBITORS; REDUCTION; POTENT; AGENTS; QUINAZOLINES; DISCOVERY; ANALOGS; FACILE;

D O I：

10.1021/cc900173s

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against a panel of human tumor cell lines, which pointed out preliminary structure-activity relationships.

引用

页码：346 / 355

页数：10

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