The role of the orphan nuclear receptor COUP-TFII in tumorigenesis

被引：36

作者：

Xu, Mafei ^{[1
]}

Qin, Jun ^{[1
,2
,3
]}

Tsai, Sophia Y. ^{[1
]}

Tsai, Ming-jer ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2015年 / 36卷 / 01期

关键词：

nuclear receptor; COUP-TFII; tumorigenesis; prostate cancer; breast cancer; PROMOTER-TRANSCRIPTION FACTOR; FACTOR-II EXPRESSION; TUMOR ANGIOGENESIS; ESTROGEN-RECEPTOR; PROSTATE-CANCER; OVALBUMIN GENE; BREAST-CANCER; GROWTH; SUPERFAMILY; CELLS;

D O I：

10.1038/aps.2014.86

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms.

引用

页码：32 / 36

页数：5

共 36 条

[1] Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans [J].

Al Turki, Saeed ;

Manickaraj, Ashok K. ;

Mercer, Catherine L. ;

Gerety, Sebastian S. ;

Hitz, Marc-Phillip ;

Lindsay, Sarah ;

D'Alessandro, Lisa C. A. ;

Swaminathan, G. Jawahar ;

Bentham, Jamie ;

Arndt, Anne-Karin ;

Low, Jacoba ;

Breckpot, Jeroen ;

Gewillig, Marc ;

Thienpont, Bernard ;

Abdul-Khaliq, Hashim ;

Harnack, Christine ;

Hoff, Kirstin ;

Kramer, Hans-Heiner ;

Schubert, Stephan ;

Siebert, Reiner ;

Toka, Okan ;

Cosgrove, Catherine ;

Watkins, Hugh ;

Lucassen, Anneke M. ;

O'Kelly, Ita M. ;

Salmon, Anthony P. ;

Bu'Lock, Frances A. ;

Granados-Riveron, Javier ;

Setchfield, Kerry ;

Thornborough, Chris ;

Brook, J. David ;

Mulder, Barbara ;

Klaassen, Sabine ;

Bhattacharya, Shoumo ;

Devriendt, Koen ;

FitzPatrick, David F. ;

Wilson, David I. ;

Mital, Seema ;

Hurles, Matthew E. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 94 (04) :574-585

[2] Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system [J].

Augustin, Hellmut G. ;

Koh, Gou Young ;

Thurston, Gavin ;

Alitalo, Kari .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (03) :165-177

[3] NR2F1 Mutations Cause Optic Atrophy with Intellectual Disability [J].

Bosch, Danielle G. M. ;

Boonstra, F. Nienke ;

Gonzaga-Jauregui, Claudia ;

Xu, Mafei ;

de Ligt, Joep ;

Jhangiani, Shalini ;

Wiszniewski, Wojciech ;

Muzny, Donna M. ;

Yntema, Helger G. ;

Pfundt, Rolph ;

Vissers, Lisenka E. L. M. ;

Spruijt, Liesbeth ;

Blokland, Ellen A. W. ;

Chen, Chun-An ;

Lewis, Richard A. ;

Tsai, Sophia Y. ;

Gibbs, Richard A. ;

Tsai, Ming-Jer ;

Lupski, James R. ;

Zoghbi, Huda Y. ;

Cremers, Frans P. M. ;

de Vries, Bert B. A. ;

Schaaf, Christian P. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 94 (02) :303-309

[4] Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[5] COUP-TFII Is a Major Regulator of Cell Cycle and Notch Signaling Pathways [J].

Chen, Xinpu ;

Qin, Jun ;

Cheng, Chiang-Min ;

Tsai, Ming-Jer ;

Tsai, Sophia Y. .

MOLECULAR ENDOCRINOLOGY, 2012, 26 (08) :1268-1277

[6]

Damiao RD, 2007, ONCOL REP, V18, P25

[7] Delineation of prognostic biomarkers in prostate cancer [J].

Dhanasekaran, SM ;

Barrette, TR ;

Ghosh, D ;

Shah, R ;

Varambally, S ;

Kurachi, K ;

Pienta, KJ ;

Rubin, MA ;

Chinnaiyan, AM .

NATURE, 2001, 412 (6849) :822-826

[8] SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression [J].

Ding, Zhihu ;

Wu, Chang-Jiun ;

Chu, Gerald C. ;

Xiao, Yonghong ;

Ho, Dennis ;

Zhang, Jingfang ;

Perry, Samuel R. ;

Labrot, Emma S. ;

Wu, Xiaoqiu ;

Lis, Rosina ;

Hoshida, Yujin ;

Hiller, David ;

Hu, Baoli ;

Jiang, Shan ;

Zheng, Hongwu ;

Stegh, Alexander H. ;

Scott, Kenneth L. ;

Signoretti, Sabina ;

Bardeesy, Nabeel ;

Wang, Y. Alan ;

Hill, David E. ;

Golub, Todd R. ;

Stampfer, Meir J. ;

Wong, Wing H. ;

Loda, Massimo ;

Mucci, Lorelei ;

Chin, Lynda ;

DePinho, Ronald A. .

NATURE, 2011, 470 (7333) :269-+

[9] E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B [J].

Engelmann, David ;

Mayoli-Nuessle, Deborah ;

Mayrhofer, Christian ;

Fuerst, Katharina ;

Alla, Vijay ;

Stoll, Anja ;

Spitschak, Alf ;

Abshagen, Kerstin ;

Vollmar, Brigitte ;

Ran, Sophia ;

Puetzer, Brigitte M. .

JOURNAL OF MOLECULAR CELL BIOLOGY, 2013, 5 (06) :391-403

[10] FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? [J].

Fischer, Christian ;

Mazzone, Massimiliano ;

Jonckx, Bart ;

Carmeliet, Peter .

NATURE REVIEWS CANCER, 2008, 8 (12) :942-956

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