Dual-targeted and MRI-guided photothermal therapy via iron-based nanoparticles-incorporated neutrophils

被引：26

作者：

Wang, Jing ^{[1
,2
]}

Mei, Tianxiao ^{[1
,2
]}

Liu, Yang ^{[1
,2
]}

Zhang, Yifan ^{[1
,2
]}

Zhang, Ziliang ^{[1
,2
]}

Hu, Yihui ^{[1
,2
]}

Wang, Yibin ^{[3
]}

Wu, Minliang ^{[4
]}

Yang, Chuanxue ^{[1
,2
]}

Zhong, Xiangdong ^{[1
,2
]}

Chen, Bingdi ^{[1
,2
]}

Cui, Zheng ^{[5
]}

Le, Wenjun ^{[1
,2
]}

Liu, Zhongmin ^{[1
,2
]}

机构：

[1] Tongji Univ, Inst Regenerat Med, Shanghai East Hosp, Inst Biomed Engn & Nano Sci,Sch Med, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China

[3] Tongji Univ, Sch Med, Dept Radiol, Shanghai East Hosp, Shanghai 200092, Peoples R China

[4] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China

[5] Wake Forest Univ, Dept Pathol, Sch Med, Winston Salem, NC 27157 USA

来源：

BIOMATERIALS SCIENCE | 2021年 / 9卷 / 11期

基金：

中国国家自然科学基金;

关键词：

INNATE IMMUNITY; DELIVERY; MICROSPHERES; NANOPLATFORM; HYPERTHERMIA;

D O I：

10.1039/d1bm00127b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Nanoparticle-mediated photothermal therapy (PTT) has shown promising capability for tumor therapy through the high local temperature at the tumor site generated by a photothermal agent (PTA) under visible or near-infrared (NIR) irradiation. Improving the accumulation of PTA at the tumor site is crucial to achieving effective photothermal treatment. Here, we developed temperature-activatable engineered neutrophils (Ne) by combining indocyanine green (ICG)-loaded magnetic silica NIR-sensitive nanoparticles (NSNP), which provide the potential for dual-targeted photothermal therapy. The combined effect of neutrophil targeting and magnetic targeting increased the accumulation of PTA at the tumor site. According to magnetic resonance imaging (MRI), the retention of intravenous injected NSNP-incorporated neutrophils within the tumor site was markedly augmented as compared to free NSNP. Furthermore, when irradiated by NIR, NSNP could cause a high local temperature at the tumor site and the thermal stimulation of neutrophils. The heat can kill tumor cells directly, and also lead to the death of neutrophils, upon which active substances with tumor-killing efficacy will be released to kill residual tumor cells and thus reduce tumor recurrence. Thereby, our therapy achieved the elimination of malignancy in the mouse model of the pancreatic tumor without recurrence. Given that all materials used in this system have been approved for use in humans, the transition of this treatment method to clinical application is plausible.

引用

页码：3968 / 3978

页数：11