Prognostic value of D-dimer/fibrinogen ratio on in-hospital outcomes of patients with heart failure and COVID-19

被引：7

作者：

Murat, Selda ^{[1
]}

Murat, Bektas ^{[2
]}

Dural, Muhammet ^{[1
]}

Mert, Gurbet Ozge ^{[1
]}

Cavusoglu, Yuksel ^{[1
]}

机构：

[1] Eskisehir Osmangazi Univ, Med Fac, Dept Cardiol, TR-26040 Eskisehir, Turkey

[2] Eskisehir City Hosp, Dept Cardiol, TR-26080 Eskisehir, Turkey

来源：

BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 16期

关键词：

coronavirus disease; D-dimer; fibrinogen ratio; heart failure; D-DIMER; PULMONARY-EMBOLISM; THROMBOEMBOLISM; GUIDELINES; DIAGNOSIS; ACCURACY;

D O I：

10.2217/bmm-2021-0341

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: In the present study, the relationship between D-dimer/fibrinogen ratio (DFR) and in-hospital outcomes was evaluated in patients with COVID-19 and a diagnosis of heart failure (HF). Materials & methods: In-hospital outcomes were compared in patients with high and low DFR values. Results: With regard to in-hospital outcomes, patients in the third tertile of DFR had a higher rate of mechanical ventilation, cardiogenic shock and death (p < 0.001). The length of ICU stay was longer in the third tertile group (p < 0.001). When evaluated together with infection markers, DFR was found to be an independent predictor of outcomes. Conclusion: DFR can be used as a prognostic marker in patients with COVID-19 with a diagnosis of HF, and perhaps more valuable than other infection markers.

引用

页码：1519 / 1528

页数：10

共 33 条

[1] COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection [J].

Al-Samkari, Hanny ;

Leaf, Rebecca S. Karp ;

Dzik, Walter H. ;

Carlson, Jonathan C. T. ;

Fogerty, Annemarie E. ;

Waheed, Anem ;

Goodarzi, Katayoon ;

Bendapudi, Pavan K. ;

Bornikova, Larissa ;

Gupta, Shruti ;

Leaf, David E. ;

Kuter, David J. ;

Rosovsky, Rachel P. .

BLOOD, 2020, 136 (04) :489-500

[2] Usefulness of measurement of fibrinogen, D-dimer, D-dimer/fibrinogen ratio, C reactive protein and erythrocyte sedimentation rate to assess the pathophysiology and mechanism of ischaemic stroke [J].

Alvarez-Perez, F. J. ;

Castelo-Branco, M. ;

Alvarez-Sabin, J. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (09) :986-992

[3] Presumed Asymptomatic Carrier Transmission of COVID-19 [J].

Bai, Yan ;

Yao, Lingsheng ;

Wei, Tao ;

Tian, Fei ;

Jin, Dong-Yan ;

Chen, Lijuan ;

Wang, Meiyun .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (14) :1406-1407

[4] Elevated levels of d-dimer are associated with inflammation and disease activity rather than risk of venous thromboembolism in patients with granulomatosis with polyangiitis in long term observation [J].

Borowiec, Anna ;

Dabrowski, Rafal ;

Kowalik, Ilona ;

Rusinowicz, Tomasz ;

Hadzik-Blaszczyk, Malorzata ;

Krupa, Renata ;

Zycinska, Katarzyna .

ADVANCES IN MEDICAL SCIENCES, 2020, 65 (01) :97-101

[5]

Ciceri F, 2020, CRIT CARE RESUSC, V22, P95

[6] COVID-19 and Cardiovascular Disease [J].

Clerkin, Kevin J. ;

Fried, Justin A. ;

Raikhelkar, Jayant ;

Sayer, Gabriel ;

Griffin, Jan M. ;

Masoumi, Amirali ;

Jain, Sneha S. ;

Burkhoff, Daniel ;

Kumaraiah, Deepa ;

Rabbani, LeRoy ;

Schwartz, Allan ;

Uriel, Nir .

CIRCULATION, 2020, 141 (20) :1648-1655

[7] Impact of congestive heart failure and role of cardiac biomarkers in COVID-19 patients: A systematic review and meta-analysis [J].

Dalia, Tarun ;

Lahan, Shubham ;

Ranka, Sagar ;

Acharya, Prakash ;

Gautam, Archana ;

Goyal, Amandeep ;

Mastoris, Ioannis ;

Sauer, Andrew ;

Shah, Zubair .

INDIAN HEART JOURNAL, 2021, 73 (01) :91-98

[8] Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation [J].

Favaloro, Emmanuel J. ;

Thachil, Jecko .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2020, 58 (08) :1191-1199

[9] Accuracy of D-dimer:fibrinogen ratio to diagnose pulmonary thromboembolism in patients admitted to intensive care units [J].

Hajsadeghi, Shokoufeh ;

Kerman, Scott R. ;

Khojandi, Mojtaba ;

Vaferi, Helen ;

Ramezani, Roza ;

Jourshari, Negar M. ;

Mousavi, Sayyed A. J. ;

Pouraliakbar, Hamidezar .

CARDIOVASCULAR JOURNAL OF AFRICA, 2012, 23 (08) :446-450

[10] Prominent changes in blood coagulation of patients with SARS-CoV-2 infection [J].

Han, Huan ;

Yang, Lan ;

Liu, Rui ;

Liu, Fang ;

Wu, Kai-lang ;

Li, Jie ;

Liu, Xing-hui ;

Zhu, Cheng-liang .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2020, 58 (07) :1116-1120

← 1 2 3 4 →