Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract

被引：25
作者：
Cai, Hong [1 ]
Thomasset, Sarah C. [1 ]
Berry, David P-. [2 ]
Garcea, Giuseppe [2 ]
Brown, Karen [1 ]
Steward, William P. [1 ]
Gescher, Andreas J. [1 ]
机构：
[1] Univ Leicester, Dept Canc Studies & Mol Med, Canc Biomarkers & Prevent Grp, Leicester LE2 7LX, Leics, England
[2] Univ Hosp Leicester, Dept Hepatobiliary & Pancreat Surg, Leicester, Leics, England
来源：
BIOMEDICAL CHROMATOGRAPHY | 2011年 / 25卷 / 06期
关键词：
anthocyanins; adsorption; metabolites; human urine; ABSORPTION; STOMACH; HUMANS;
D O I：
10.1002/bmc.1499
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Anthocyanins possess cancer chemopreventive properties in preclinical models. Their clinical pharmacology is only poorly understood. In this pilot study, anthocyanins and their metabolites were analysed in the urine of two patients with colorectal liver metastases. They received a single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver resection. HPLC-MS/MS and HPLC-UV analysis showed there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum. This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption. Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码：660 / 663
页数：4
相关论文
共 9 条
[1]   Anthocyans from fruits and vegetables - Does bright colour signal cancer chemopreventive activity? [J].
Cooke, D ;
Steward, WP ;
Gescher, AJ ;
Marczylo, T .
EUROPEAN JOURNAL OF CANCER, 2005, 41 (13) :1931-1940
[2]   Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine [J].
Cooke, Darren N. ;
Thomasset, Sarah ;
Boocock, David J. ;
Schwarz, Michael ;
Winterhalter, Peter ;
Steward, William P. ;
Gescher, Andreas J. ;
Marczylo, Timothy H. .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (19) :7009-7013
[3]   Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms [J].
Matsumoto, H ;
Inaba, H ;
Kishi, M ;
Tominaga, S ;
Hirayama, M ;
Tsuda, T .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (03) :1546-1551
[4]   Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats [J].
McGhie, TK ;
Ainge, GD ;
Barnett, LE ;
Cooney, JM ;
Jensen, DJ .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (16) :4539-4548
[5]   The bioavailability and absorption of anthocyanins: Towards a better understanding [J].
McGhie, Tony K. ;
Walton, Michaela C. .
MOLECULAR NUTRITION & FOOD RESEARCH, 2007, 51 (06) :702-713
[6]   The stomach as a site for anthocyanins absorption from food [J].
Passamonti, S ;
Vrhovsek, U ;
Vanzo, A ;
Mattivi, F .
FEBS LETTERS, 2003, 544 (1-3) :210-213
[7]   Anthocyanins are efficiently absorbed from the stomach in anesthetized rats [J].
Talavéra, S ;
Felgines, C ;
Texier, O ;
Besson, C ;
Lamaison, JL ;
Rémésy, C .
JOURNAL OF NUTRITION, 2003, 133 (12) :4178-4182
[8]   Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention [J].
Thomasset, Sarah ;
Berry, David P. ;
Cai, Hong ;
West, Kevin ;
Marczylo, Tim H. ;
Marsden, Debbie ;
Brown, Karen ;
Dennison, Ashley ;
Garcea, Giuseppe ;
Miller, Andrew ;
Hemingway, David ;
Steward, William P. ;
Gescher, Andreas J. .
CANCER PREVENTION RESEARCH, 2009, 2 (07) :625-633
[9]   Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? [J].
Thomasset, Sarah ;
Teller, Nicole ;
Cai, Hong ;
Marko, Doris ;
Berry, David P. ;
Steward, William P. ;
Gescher, Andreas J. .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2009, 64 (01) :201-211
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