Antifungal polysulphides from Petiveria alliacea L.

被引：53
作者：
Benevides, PJC
Young, MCM
Giesbrecht, AM
Roque, NF
Bolzani, VDS
机构：
[1] Univ Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
[2] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo, Brazil
[3] Inst Bot, Dept Fisiol & Bioquim Plantas, BR-01161970 Sao Paulo, Brazil
来源：
PHYTOCHEMISTRY | 2001年 / 57卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
Petiveria alliacea; Phytolacaceae; antifungal polysulphides;
D O I：
10.1016/S0031-9422(01)00079-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioactivity-directed fractionation of the CH2Cl2/MeOH (2:1, v/v) extract of the roots of Petiveria alliacea, using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of dipropyl disulphide (1), dibenzyl sulphide (2), dibenzyl disulphide (3), dibenzyl trisulphide (4), dibenzyl tetrasulphide (5), benzylhydroxymethyl sulphide (6) and di(benzyltrithio) methane (7). Of these, 5-7 are new compounds and this is the first report of the natural occurrence of 2 and 3. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：743 / 747
页数：5
相关论文
共 12 条
[1]   TRITHIOLANIACIN, A NOVEL TRITHIOLAN FROM PETIVERIA-ALLIACEA [J].
ADESOGAN, EK .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1974, (21) :906-907
[2]  
[Anonymous], 1939, PLANTAS SUBSTANCIAS
[3]   Iridoid and seco-iridoid glucosides from Chioccoca alba (Rubiaceae) [J].
Carbonezi, CA ;
Martins, D ;
Young, MCM ;
Lopes, MN ;
Furlan, M ;
Rodrigues, E ;
Bolzani, VDS .
PHYTOCHEMISTRY, 1999, 51 (06) :781-785
[4]  
CORREA MP, 1969, DICIONARIO PLANTAS U
[5]  
DASILVA RA, 1935, REV FLORA MED, V9, P477
[6]  
DELLEMONACHE F, 1992, PHYTOCHEMISTRY, V31, P2481, DOI 10.1016/0031-9422(92)83304-H
[7]   DIBENZYL TRISULFIDE AND TRANS-N-METHYL-4-METHOXYPROLINE FROM PETIVERIA-ALLIACEA [J].
DESOUSA, JR ;
DEMUNER, AJ ;
PINHEIRO, JA ;
BREITMAIER, E ;
CASSELS, BK .
PHYTOCHEMISTRY, 1990, 29 (11) :3653-3655
[8]  
DESOUSA JR, 1987, CIENC CULT-SAO PAULO, V39, P645
[9]   MECHANISM-BASED ISOLATION AND STRUCTURE OF SOME ANTICANCER ACTIVE NATURAL-PRODUCTS [J].
GUNATILAKA, AAL ;
KINGSTON, DGI ;
JOHNSON, RK .
PURE AND APPLIED CHEMISTRY, 1994, 66 (10-11) :2219-2222
[10]  
GUNATILAKA AAL, 1992, J NAT PRODUCTS, V5, P1548
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