A new ICT and CHEF based visible light excitable fluorescent probe easily detects in vivo Zn2+

被引：63

作者：

Aich, Krishnendu ^{[1
]}

Goswami, Shyamaprosad ^{[1
]}

Das, Sangita ^{[1
]}

Das Mukhopadhyay, Chitrangada ^{[2
]}

机构：

[1] Indian Inst Engn Sci & Technol, Dept Chem, Sibpur 711103, Howrah, India

[2] Indian Inst Engn Sci & Technol, Ctr Healthcare Sci & Technol, Sibpur 711103, Howrah, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 39期

关键词：

TURN-ON PROBE; SELECTIVE DETECTION; RATIOMETRIC DETECTION; COLORIMETRIC SENSOR; AQUEOUS-SOLUTION; ZINC IONS; CHEMOSENSOR; RECOGNITION; CD2+; NEUROBIOLOGY;

D O I：

10.1039/c5ra03353e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new chelator and ICT donor based visible light excitable Zn2+ sensor was designed and developed by integrating quinoline and 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde. The probe is sensitive towards Zn2+ in absorbance as well as in fluorescence experiments in 90% aqueous medium. The sensor demonstrates Zn2+-specific emission enhancement due to the ICT and CHEF process with the LOD in the range of 10(-8) M. The fluorescence quantum yield of the chemosensor is only 0.02, and it increases almost 11-fold (0.22) after complexation with Zn2+. Interestingly, the introduction of other metal ions causes the fluorescence intensity to remain almost unchanged. Moreover, the ability of the probe (BQ) to sense Zn2+ in living cells has been explored.

引用

页码：31189 / 31194

页数：6

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