Detection of susceptibility loci on APOA5 and COLEC12 associated with metabolic syndrome using a genome-wide association study in a Taiwanese population

被引:24
|
作者
Lin, Eugene [1 ,2 ,3 ]
Kuo, Po-Hsiu [4 ]
Liu, Yu-Li [5 ]
Yang, Albert C. [6 ,7 ,8 ]
Tsai, Shih-Jen [6 ,7 ]
机构
[1] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
[2] Vita Genom Inc, Taipei, Taiwan
[3] TickleFish Syst Corp, Seattle, WA USA
[4] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Dept Publ Hlth, Taipei, Taiwan
[5] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Miaoli, Miaoli County, Taiwan
[6] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan
[7] Natl Yang Ming Univ, Div Psychiat, Taipei, Taiwan
[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Interdisciplinary Med & Biotechnol, Boston, MA USA
关键词
gene-gene interactions; genome-wide association studies; metabolic syndrome; single nucleotide polymorphisms; Pathology Section; APOLIPOPROTEIN A5 GENE; MEDIATOR COMPLEX; SCAVENGER RECEPTOR; TELOMERE LENGTH; RISK; POLYMORPHISM; VARIANT; PHENOTYPES; CHINESE; OBESITY;
D O I
10.18632/oncotarget.20967
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Although the association of single nucleotide polymorphisms (SNPs) with metabolic syndrome (MetS) has been reported in various populations in several genome-wide association studies (GWAS), the data is not conclusive. In this GWAS study, we assessed whether SNPs are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. Methods: A total of 10,300 Taiwanese subjects were assessed in this study. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Results: Our data showed an association of MetS at the genome-wide significance level (P < 8.6 x 10(-8)) with two SNPs, including the rs662799 SNP in the apolipoprotein A5 (APOA5) gene and the rs16944558 SNP in the collectin subfamily member 12 (COLEC12) gene. Moreover, we identified the effect of APOA5 rs662799 on triglyceride and HDL, the effect of rs1106475 in the actin filament associated protein 1 like 2 (AFAP1L2) gene on systolic blood pressure, and the effect of rs17667932 in the mediator complex subunit 30 (MED30) gene on fasting glucose. Additionally, we found that an interaction between the APOA5 rs662799 and COLEC12 rs16944558 SNPs influenced MetS, high triglyceride, and low HDL. Conclusions: Our study indicates that the APOA5 and COLEC12 genes may contribute to the risk of MetS and its individual components independently as well as through gene-gene interactions.
引用
收藏
页码:93349 / 93359
页数:11
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