adoptive cell transfer;
gamma;
delta T cells;
glioblastoma;
immunotherapy;
NK cells;
NKG2D ligand;
receptor;
DELTA-T-CELLS;
I-RELATED CHAIN;
NEWLY-DIAGNOSED GLIOBLASTOMA;
GROWTH-FACTOR-BETA;
NK CELLS;
TGF-BETA;
ANTIGEN RECEPTOR;
LIGANDS CONTRIBUTES;
DOWN-REGULATION;
SOLUBLE MICB;
D O I:
10.1111/sji.13201
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Glioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the blood-brain barrier shields the brain from immune surveillance. In this review, we discuss the composition of the immunosuppressive tumour micromilieu and potential immune escape mechanisms in GBM. In this respect, we focus on the role of the NKG2D receptor/ligand system. NKG2D ligands are frequently expressed on GBM tumour cells and can activate NKG2D-expressing killer cells including NK cells and gamma delta T cells. Soluble NKG2D ligands, however, contribute to tumour escape from immunological attack. We also discuss the current immunotherapeutic strategies to improve the survival of GBM patients. Such approaches include the modulation of the NKG2D receptor/ligand system, the application of checkpoint inhibitors, the adoptive transfer of ex vivo expanded and/or modified immune cells or the application of antibodies and antibody constructs to target cytotoxic effector cells in vivo. In view of the multitude of pursued strategies, there is hope for improved overall survival of GBM patients in the future.
机构:
Univ Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USAUniv Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Akins, Erin A.
Aghi, Manish K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USAUniv Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Aghi, Manish K.
Kumar, Sanjay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USAUniv Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
机构:
Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Almeida, Afonso R.
Correia, Daniel V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Correia, Daniel V.
Fernandes-Platzgummer, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Inst Super Tecn, Dept Bioenginee & IBB Inst Bioengineer & Biosci, Lisbon, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Fernandes-Platzgummer, Ana
da Silva, Claudia L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Inst Super Tecn, Dept Bioenginee & IBB Inst Bioengineer & Biosci, Lisbon, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
da Silva, Claudia L.
da Silva, Maria Gomes
论文数: 0引用数: 0
h-index: 0
机构:
Inst Portugu Oncol Lisboa Francisco Gentil, Lisbon, Portugal
Univ Nova Lisboa, Fac Cienc Med, Lisbon, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
da Silva, Maria Gomes
Anjos, Diogo Remechido
论文数: 0引用数: 0
h-index: 0
机构:
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Anjos, Diogo Remechido
Silva-Santos, Bruno
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
机构:
Univ Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USAUniv Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Akins, Erin A.
Aghi, Manish K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USAUniv Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Aghi, Manish K.
Kumar, Sanjay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USAUniv Calif Berkeley, Univ Calif San Francisco, San Francisco Grad Program Bioengn, Berkeley, CA 94720 USA
机构:
Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Almeida, Afonso R.
Correia, Daniel V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Correia, Daniel V.
Fernandes-Platzgummer, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Inst Super Tecn, Dept Bioenginee & IBB Inst Bioengineer & Biosci, Lisbon, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Fernandes-Platzgummer, Ana
da Silva, Claudia L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Inst Super Tecn, Dept Bioenginee & IBB Inst Bioengineer & Biosci, Lisbon, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
da Silva, Claudia L.
da Silva, Maria Gomes
论文数: 0引用数: 0
h-index: 0
机构:
Inst Portugu Oncol Lisboa Francisco Gentil, Lisbon, Portugal
Univ Nova Lisboa, Fac Cienc Med, Lisbon, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
da Silva, Maria Gomes
Anjos, Diogo Remechido
论文数: 0引用数: 0
h-index: 0
机构:
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Anjos, Diogo Remechido
Silva-Santos, Bruno
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal
Lymphact Lymphocyte Activat Technol, Coimbra, PortugalUniv Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal