Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral

被引：92
作者：
Gustafsson, Tomas [1 ]
Ponten, Fritiof [2 ]
Seeberger, Peter H. [1 ]
机构：
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
[2] AstraZeneca R&D, S-43183 Molndal, Sweden
来源：
CHEMICAL COMMUNICATIONS | 2008年 / 09期
关键词：
D O I：
10.1039/b719603b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.
引用
收藏
页码：1100 / 1102
页数：3
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