Disturbances of varying frequency and intensity shape the species composition, stand structure, and functions of forests. This study assessed the frequency and distribution of disturbances caused by eight agents (insects, diseases, fire, animals, weather, other vegetation, human, and unknown) in the forests of the southeastern United States from 1995 to 2018. We used data from 88,722 inventory measurements of 33,531 plots from the USDA Forest Inventory and Analysis database to assess disturbance among different forest types and to different canopy strata. Disturbances were detected in approximately 14 percent of the plots, located mostly in pine-dominated forest types. Fire was the most frequent disturbance agent (occurring 6 percent of the time), followed by weather and animal agents. The agents that caused the highest mortality rate during the period for saplings were silvicultural treatments (8.6 percent), other vegetation (5.6 percent), and fire (4.4 percent), whereas for trees they were silvicultural treatments (9.8 percent), weather (1.9 percent) and insects (1.7 percent). The forest type that appeared to have been most affected by disturbances was longleaf-slash pine of the Coastal Plain. These results are useful for understanding the spatiotemporal distribution of disturbance events in different southeastern forest types and locations and for guiding forest management activities to mitigate potential impacts. Study Implications: This study examined the spatiotemporal variation in the occurrence of eight disturbance agents across the forest types of the southeastern United States. Forest managers can benefit from these results to plan for appropriate treatments for maintaining and restoring ecosystem resilience and function. We recommend a natural disturbance-based management approach that embraces and emulates the effect of natural disturbances, such as frequent and low-severity fires, moderate ice accumulations, and intermediate-scale winds. Foresters can use the results from our study as well as additional data and information to understand the disturbance regime of their forest type, physiographic region, or state and decide on whether to implement any silvicultural treatment. For example, since the observed frequency of damage because of suppression of overtopped trees, competition, and smothering by vines in large tree diameter stands of longleaf-slash pine in Alabama and Georgia was significantly higher than expected, control of undesired trees and vines through mechanical and chemical methods and use of prescribed fires would be an appropriate prescription for these stands. Recommendations for stands managed for objectives such as wildlife habitat or recreation would be different from those for stands being used primarily for timber production.