Biosensors for circulating tumor cells (CTCs)-biomarker detection in lung and prostate cancer: Trends and prospects

被引：59
作者：
Hussain, Syed Harris [1 ,2 ,3 ]
Huertas, Cesar S. [3 ]
Mitchell, Arnan [3 ]
Deman, Anne-Laure [2 ]
Laurenceau, Emmanuelle [1 ]
机构：
[1] Univ Lyon, Univ Claude Bernard Lyon 1, UMR5270, INL,Ecole Cent Lyon,CNRS,INSA Lyon,CPE Lyon, F-69130 Ecully, France
[2] Univ Lyon, Univ Claude Bernard Lyon 1, UMR5270, INL,CNRS,INSA Lyon,Ecole Cent Lyon,CPE Lyon, F-69622 Villeurbanne, France
[3] RMIT Univ, Integrated Photon & Applicat Ctr, Sch Engn, Melbourne, Vic 3001, Australia
来源：
BIOSENSORS & BIOELECTRONICS | 2022年 / 197卷
关键词：
Lung cancer; Prostate cancer; Circulating tumor cells; Biomarkers; Biosensors; CRYSTAL MICROBALANCE BIOSENSOR; LABEL-FREE DETECTION; PROGNOSTIC VALUE; CARCINOEMBRYONIC ANTIGEN; EXPRESSION; GROWTH; FIBRONECTIN; BIOMARKERS; CARCINOMA; DIAGNOSIS;
D O I：
10.1016/j.bios.2021.113770
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Cancer is one of the leading cause of death worldwide. Lung cancer (LCa) and prostate cancer (PCa) are the two most common ones particularly among men with about 20% of aggressive metastatic form leading to shorter overall survival. In recent years, circulating tumor cells (CTCs) have been investigated extensively for their role in metastatic progression and their involvement in reduced overall survival and treatment responses. Analysis of these cells and their associated biomarkers as "liquid biopsy" can provide valuable real-time information regarding the disease state and can be a potential avenue for early-stage detection and possible selection of personalized treatments. This review focuses on the role of CTCs and their associated biomarkers in lung and prostate cancer, as well as the shortcomings of conventional methods for their isolation and analysis. To over-come these drawbacks, biosensors are an elegant alternative because they are capable of providing valuable multiplexed information in real-time and analyzing biomarkers at lower concentrations. A comparative analysis of different transducing elements specific for the analysis of cancer cell and cancer biomarkers have been compiled in this review.
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页数：14
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