Synthesis of Indolizines via Palladium Catalyzed Annulation of Propargyl Carbonates and 2-(Pyridin-2-yl)acetonitrile Derivatives

被引：36
|
作者：
Wu, Ting [1 ,2 ]
Chen, Min [1 ,2 ]
Yang, Yuzhu [1 ,2 ]
机构：
[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China
[2] Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 20期
关键词：
EFFICIENT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; 1,3-DIPOLAR CYCLOADDITION; CASCADE; 2-ALKYLAZAARENES; CYCLIZATION; ACTIVATION; ARYLATION; ALKYNES; YLIDES;
D O I：
10.1021/acs.joc.7b02278
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd-catalyzed regioselective annulation reaction of propargyl carbonates and 2-(pyridine-2-y1) acetonitrile derivatives has been accomplished, which provides a straightforward and efficient access to polysubstituted indolizines. The choice of the phosphine ligand is crucial to the high regio-selectivity of the reaction.
引用
收藏
页码：11304 / 11309
页数：6
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