Synthesis of Indolizines via Palladium Catalyzed Annulation of Propargyl Carbonates and 2-(Pyridin-2-yl)acetonitrile Derivatives

被引：36

作者：

Wu, Ting ^{[1
,2
]}

Chen, Min ^{[1
,2
]}

Yang, Yuzhu ^{[1
,2
]}

机构：

[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China

[2] Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 20期

关键词：

EFFICIENT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; 1,3-DIPOLAR CYCLOADDITION; CASCADE; 2-ALKYLAZAARENES; CYCLIZATION; ACTIVATION; ARYLATION; ALKYNES; YLIDES;

D O I：

10.1021/acs.joc.7b02278

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed regioselective annulation reaction of propargyl carbonates and 2-(pyridine-2-y1) acetonitrile derivatives has been accomplished, which provides a straightforward and efficient access to polysubstituted indolizines. The choice of the phosphine ligand is crucial to the high regio-selectivity of the reaction.

引用

页码：11304 / 11309

页数：6

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