The influence of early-life microbial exposures on long-term respiratory health

被引:8
作者
Taylor, Steven L. [1 ,2 ]
Simpson, Jodie L. [3 ,4 ]
Rogers, Geraint B. [1 ,2 ,4 ]
机构
[1] Flinders Univ S Australia, Coll Med & Publ Hlth, SAHMRI Microbiome Res Lab, Adelaide, SA 5000, Australia
[2] South Australia Hlth & Med Res Inst, Microbiome & Host Hlth, North Terrace, Adelaide, SA 5000, Australia
[3] Univ Newcastle, Fac Hlth & Med, Prior Res Ctr Hlth Lungs, Callaghan, NSW, Australia
[4] Hunter Med Res Inst, Room 5-332,Flinders Med Ctr,Bedford Pk, Newcastle, NSW 5042, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
Microbiota; Infant; Asthma; Pulmonary disease; Chronic obstructive; Anti-bacterial agents; Premature birth; Hypersensitivity; INTESTINAL MICROBIOTA; ANTIBIOTIC EXPOSURE; IMMUNE-RESPONSES; GUT MICROBIOTA; ASTHMA; RISK; INFANTS; MORTALITY; ALLERGY; SEPSIS;
D O I
10.1016/j.prrv.2021.05.003
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Host-microbiome interactions exert a profound influence on human physiology and health outcomes. In particular, certain characteristics of commensal microbiota during a critical period in early life are essen-tial for the establishment of immune tone and metabolic control. An increasing body of evidence suggests that early life exposures that disrupt these interactions can substantially influence life-long risks for res-piratory disease. Here, we explore how such early life exposures, including antibiotic exposure, maternal diet, preterm birth, mode of delivery, breastfeeding, and environmental variables shape the infant micro-biome, and the mechanisms by such changes can in turn impact respiratory health. (c) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页码:15 / 23
页数:9
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