Signal processing in complex chemotaxis pathways

被引：350

作者：

Porter, Steven L. ^{[2
]}

Wadhams, George H. ^{[1
]}

Armitage, Judith P. ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford Ctr Integrat Syst Biol, Oxford OX1 3QU, England

[2] Univ Exeter, Coll Life & Environm Sci, Exeter EX4 4QD, Devon, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

RHODOBACTER-SPHAEROIDES REQUIRES; HISTIDINE PROTEIN-KINASE; ESCHERICHIA-COLI; BACTERIAL CHEMOTAXIS; PSEUDOMONAS-AERUGINOSA; FLAGELLAR MOTOR; ENERGY TAXIS; CHEMOSENSORY PATHWAYS; TRANSDUCTION CASCADE; CHEY-P;

D O I：

10.1038/nrmicro2505

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacteria use chemotaxis to migrate towards environments that are better for growth. Chemoreceptors detect changes in attractant levels and signal through two-component systems to control swimming direction. This basic pathway is conserved across all chemotactic bacteria and archaea; however, recent work combining systems biology and genome sequencing has started to elucidate the additional complexity of the process in many bacterial species. This article focuses on one of the best understood complex networks, which is found in Rhodobacter sphaeroides and integrates sensory data about the external environment and the metabolic state of the cell to produce a balanced response at the flagellar motor.

引用

页码：153 / 165

页数：13

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