Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds

被引：360

作者：

Yazdanian, M ^{[1
]}

Glynn, SL ^{[1
]}

Wright, JL ^{[1
]}

Hawi, A ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Pharmaceut, Ridgefield, CT 06877 USA

来源：

PHARMACEUTICAL RESEARCH | 1998年 / 15卷 / 09期

关键词：

Caco-2; cells; permeability; partitioning; octanol; hexadecane; propyleneglycol dipelargonate;

D O I：

10.1023/A:1011930411574

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1490 / 1494

页数：5

共 23 条

[1] CORRELATION BETWEEN ORAL-DRUG ABSORPTION IN HUMANS AND APPARENT DRUG PERMEABILITY COEFFICIENTS IN HUMAN INTESTINAL EPITHELIAL (CACO-2) CELLS [J].

ARTURSSON, P ;

KARLSSON, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) :880-885

[2]

ARTURSSON P, 1991, CRIT REV THER DRUG, V8, P305

[3] Caco-2 monolayers in experimental and theoretical predictions of drug transport [J].

Artursson, P ;

Palm, K ;

Luthman, K .

ADVANCED DRUG DELIVERY REVIEWS, 1996, 22 (1-2) :67-84

[4]

BURTON PS, 1992, J CONTROL RELEASE, V19, P87, DOI 10.1016/0168-3659(92)90067-2

[5] Permeability of 5-fluorouracil and prodrugs in Caco-2 cell monolayers. [J].

Buur, A ;

Trier, L ;

Magnusson, C ;

Artursson, P .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 129 (1-2) :223-231

[6]

GOODMAN LS, 1970, PHARMACOL BASIS THER, P334

[7]

HIDALGO IJ, 1989, GASTROENTEROLOGY, V96, P736

[8] CACO-2 CELL MONOLAYERS AS A MODEL FOR DRUG TRANSPORT ACROSS THE INTESTINAL-MUCOSA [J].

HILGERS, AR ;

CONRADI, RA ;

BURTON, PS .

PHARMACEUTICAL RESEARCH, 1990, 7 (09) :902-910

[9] DRUG-DELIVERY STUDIES IN CACO-2 MONOLAYERS - SYNTHESIS, HYDROLYSIS, AND TRANSPORT OF O-CYCLOPROPANE CARBOXYLIC-ACID ESTER PRODRUGS OF VARIOUS BETA-BLOCKING-AGENTS [J].

HOVGAARD, L ;

BRONDSTED, H ;

BUUR, A ;

BUNDGAARD, H .

PHARMACEUTICAL RESEARCH, 1995, 12 (03) :387-392

[10]

JACK DB, 1992, HDB CLIN PHARMACOKIN, P25

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