The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism

被引：45

作者：

Ajram, Laura A. ^{[1
,2
]}

Pereira, Andreia C. ^{[1
,2
,3
]}

Durieux, Alice M. S. ^{[1
,2
]}

Velthius, Hester E. ^{[1
]}

Petrinovic, Marija M. ^{[1
,2
]}

McAlonan, Grainne M. ^{[1
,2
]}

机构：

[1] Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat Psychol & Neurosci, 16 De Crespigny Pk, London SE5 8AF, England

[2] Kings Coll London, Sackler Inst Translat Neurodev, Inst Psychiat Psychol & Neurosci, 16 De Crespigny Pk, London SE5 8AF, England

[3] Univ Coimbra, Fac Med, ICNAS Inst Nucl Sci Appl Hlth, CIBIT Coimbra Inst Biomed Imaging & Translat Res, Polo 3, P-3000548 Coimbra, Portugal

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2019年 / 89卷

关键词：

Autism; Excitation-inhibition; GABA; Glutamate; Magnetic resonance spectroscopy; GAMMA-AMINOBUTYRIC-ACID; EDITED MR SPECTROSCOPY; COPY NUMBER VARIANTS; IN-VIVO DETECTION; SPECTRUM DISORDER; GABA(A) RECEPTOR; SYNAPTIC-TRANSMISSION; CINGULATE CORTEX; DOWN-REGULATION; VALPROIC ACID;

D O I：

10.1016/j.pnpbp.2018.09.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Autism spectrum disorder (ASD) affects over 1:100 of the population and costs the UK more than (sic)32bn and the USA more than $175bn ((sic)104bn) annually. Its core symptoms are social and communication difficulties, repetitive behaviours and sensory hyper- or hypo-sensitivities. A highly diverse phenotypic presentation likely reflects its etiological heterogeneity and makes finding treatment targets for ASD challenging. In addition, there are no means to identify biologically responsive individuals who may benefit from specific interventions. There is hope however, and in this review we consolidate how findings from magnetic resonance spectroscopy (MRS) add to the evidence that differences in the brain's excitatory glutamate and inhibitory gamma-aminobutyric acid (GABA) balance may be both a key biomarker and a tractable treatment target in ASD.

引用

页码：236 / 244

页数：9

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