An Alternative Lidocaine Hydrochloride Liposomal Gel Formulation: Preparation, Percutaneous Permeation and Release Kinetics

被引：0

作者：

Zhang, Xue-Nong ^{[1
]}

Gong, Jin-hong ^{[1
]}

Liu, Yang ^{[1
]}

Tang, Li-hua ^{[1
]}

Xu, Xiao-jun

机构：

[1] Soochow Univ, Coll Pharm, Suzhou 215123, Peoples R China

来源：

2009 3RD INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING, VOLS 1-11 | 2009年

关键词：

Lidocaine hydrochloride (LDH); Liposome; Gel; Percutaneous permeation; DRUG-DELIVERY;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Liposomal hydrogel formulations of lidocaine hydrochloride(LDH)have been prepared and drug percutaneous permeation and release properties in vitro have been evaluated. An optimal hydrogel prescription with carbopol as base involved permeation enhancers as polyethylene glycol (PEG-400), Azone, poloxamer and propylene glycol was screened in vitro. Percutaneous permeation kinetic models of LDH in three formulations: liposome solution, conventional gel and liposomal gel were studied.

引用

页码：1549 / +

页数：2

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