Use of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection

被引：15

作者：

Chi, Jingmao ^{[1
]}

Zaw, Thet ^{[2
]}

Cardona, Iliana ^{[2
]}

Hosnain, Mujtaba ^{[2
]}

Garg, Neha ^{[2
]}

Lefkowitz, Heather R. ^{[2
]}

Tolias, Peter ^{[3
]}

Du, Henry ^{[1
]}

机构：

[1] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA

[2] Newark Beth Israel Med Ctr, Newark, NJ 07112 USA

[3] Ctr Healthcare Innovat, Stevens Inst Technol, Hoboken, NJ 07030 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 03期

关键词：

HEMATURIA; SILVER;

D O I：

10.1364/BOE.6.000761

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report an early, noninvasive and rapid prognostic method of predicting potential acute kidney dysfunction using surface-enhanced Raman scattering (SERS). Our analysis was performed on urine samples collected prospectively from 58 kidney transplant patients using a He-Ne laser (632.8 nm) as the excitation source. All abnormal kidney function episodes (three acute rejections and two acute kidney failures that were eventually diagnosed independently by clinical biopsy) consistently exhibited unique SERS spectral features in just one day following the transplant surgery. These results suggested that SERS analysis provides an early and more specific indication to kidney function than the clinically used biomarker, serum creatinine (sCr). (C) 2015 Optical Society of America

引用

页码：761 / 769

页数：9

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