Obesity, smooth muscle, and airway hyperresponsiveness

被引:168
作者
Shore, SA [1 ]
Fredberg, JJ [1 ]
机构
[1] Harvard Univ, Sch Publ Hlth, Physiol Program, Boston, MA 02115 USA
关键词
leptin; adiponectin; plasminogen activator inhibitor; inflammation; TNF;
D O I
10.1016/j.jaci.2005.01.064
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Both asthma and obesity are large and growing public health issues. Mounting evidence now implicates obesity as a major risk factor for asthma, thus linking these 2 major epidemics. Moreover, both in human subjects and in mice, obesity appears to predispose toward airway hyperresponsiveness. This review describes potential mechanisms whereby obesity might modify airway smooth muscle function to explain these observations. These mechanisms include both static and dynamic mechanical factors attributable to decreases in functional residual capacity and decreases in tidal volume that are observed in the obese. They include also obesity-related changes in lung development, chronic systemic inflammation (including increased serum levels of inflammatory cytokines and chemokines), and adipocyte-derived factors, including leptin, adiponectin, and plasminogen activator inhibitor.
引用
收藏
页码:925 / 927
页数:3
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