Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline

被引：84

作者：

Freyer, David R. ^{[1
,2
,3
]}

Brock, Penelope R. ^{[4
]}

Chang, Kay W. ^{[5
]}

Dupuis, L. Lee ^{[6
,7
,9
]}

Epelman, Sidnei ^{[10
]}

Knight, Kristin ^{[11
]}

Mills, Denise ^{[8
,12
]}

Phillips, Robert ^{[13
,14
]}

Potter, Emma ^{[15
]}

Risby, Demie ^{[16
]}

Simpkin, Philippa

Sullivan, Michael ^{[17
,18
]}

Cabral, Sandra ^{[12
]}

Robinson, Paula D. ^{[12
]}

Sung, Lillian ^{[7
,8
]}

机构：

[1] Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Los Angeles, CA 90027 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90007 USA

[4] Great Ormond St Hosp Sick Children, Dept Haematol & Oncol, London, England

[5] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Palo Alto, CA 94304 USA

[6] Hosp Sick Children, Dept Pharm, Toronto, ON, Canada

[7] Hosp Sick Children, Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada

[8] Hosp Sick Children, Div Haematol & Oncol, Toronto, ON M5G 1X8, Canada

[9] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada

[10] Casa Saude Santa Marcelina, Dept Pediat Oncol, Sao Paulo, Brazil

[11] Oregon Hlth & Sci Univ, Doernbecher Childrens Hosp, Pediat Audiol, Portland, OR 97201 USA

[12] Pediat Oncol Grp Ontario, Toronto, ON, Canada

[13] Leeds Teaching Hosp, NHS Trust, Dept Haematol & Oncol, Leeds, W Yorkshire, England

[14] Univ York, Ctr Reviews & Disseminat, York, N Yorkshire, England

[15] Royal Marsden Hosp, Div Oncol, London, England

[16] Great Ormond St Hosp Sick Children, London, England

[17] Royal Childrens Hosp, Childrens Canc Ctr, Melbourne, Vic, Australia

[18] Univ Melbourne, Fac Med, Dept Paediat, Melbourne, Vic, Australia

来源：

LANCET CHILD & ADOLESCENT HEALTH | 2020年 / 4卷 / 02期

关键词：

INDUCED HEARING-LOSS; PLATINUM-INDUCED OTOTOXICITY; HIGH-DOSE CISPLATIN; INDUCED TOXICITIES; N-ACETYLCYSTEINE; DOUBLE-BLIND; NECK-CANCER; SODIUM THIOSULFATE; PHASE-II; PROTECTION;

D O I：

10.1016/S2352-4642(19)30336-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Despite ototoxicity being a prevalent consequence of cisplatin chemotherapy, little guidance exists on interventions to prevent this permanent and progressive adverse event. To develop a clinical practice guideline for the prevention of cisplatin-induced ototoxicity in children and adolescents with cancer, we convened an international, multidisciplinary panel of experts and patient advocates to update a systematic review of randomised trials for the prevention of cisplatin-induced ototoxicity. The systematic review identified 27 eligible adult and paediatric trials that evaluated amifostine, sodium diethyldithiocarbamate or disulfiram, systemic sodium thiosulfate, intratympanic therapies, and cisplatin infusion duration. Regarding systemic sodium thiosulfate, the panel made a strong recommendation for administration in non-metastatic hepatoblastoma, a weak recommendation for administration in other non-metastatic cancers, and a weak recommendation against its routine use in metastatic cancers. Amifostine, sodium diethyldithiocarbamate, and intratympanic therapy should not be routinely used. Cisplatin infusion duration should not be altered as a means to reduce ototoxicity. Further research to determine the safety of sodium thiosulfate in patients with metastatic cancer is encouraged.

引用

页码：141 / 150

页数：10

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