Mitochondria-Targeted Reaction-Based Fluorescent Probe for Hydrogen Sulfide

被引：226

作者：

Pak, Yen Leng ^{[1
]}

Li, Jun ^{[1
]}

Ko, Kyoung Chul ^{[2
]}

Kim, Gyoungmi ^{[1
]}

Lee, Jin Yong ^{[2
]}

Yoon, Juyoung ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[2] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea

来源：

ANALYTICAL CHEMISTRY | 2016年 / 88卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

TURN-ON PROBE; SELECTIVE DETECTION; RAPID DETECTION; 2-PHOTON PROBE; FAST-RESPONSE; LIVING CELLS; IN-VIVO; H2S; GASOTRANSMITTER; CHEMOSENSOR;

D O I：

10.1021/acs.analchem.6b00956

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, we developed a turn-on mitochondria-targeting hydrogen sulfide, "probe 1", based on the selective thiolysis of 7-nitro-1,2,3-benzoxadiazole amine moiety attached to the piperazine-based naphthalimide scaffold. Probe 1 exhibited excellent properties with 68-fold fluorescence enhancement, a low detection limit (2.46 mu M), a low cytotoxicity, and a good selectivity toward hydrogen sulfide. The success of intracellular imaging indicated that probe 1 could be used in further applications for the investigation of biological functions and pathological roles of H2S in living systems.

引用

页码：5476 / 5481

页数：6

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