Mitochondria-Targeted Reaction-Based Fluorescent Probe for Hydrogen Sulfide

被引：226
|
作者：
Pak, Yen Leng [1 ]
Li, Jun [1 ]
Ko, Kyoung Chul [2 ]
Kim, Gyoungmi [1 ]
Lee, Jin Yong [2 ]
Yoon, Juyoung [1 ]
机构：
[1] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
[2] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea
来源：
ANALYTICAL CHEMISTRY | 2016年 / 88卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
TURN-ON PROBE; SELECTIVE DETECTION; RAPID DETECTION; 2-PHOTON PROBE; FAST-RESPONSE; LIVING CELLS; IN-VIVO; H2S; GASOTRANSMITTER; CHEMOSENSOR;
D O I：
10.1021/acs.analchem.6b00956
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this study, we developed a turn-on mitochondria-targeting hydrogen sulfide, "probe 1", based on the selective thiolysis of 7-nitro-1,2,3-benzoxadiazole amine moiety attached to the piperazine-based naphthalimide scaffold. Probe 1 exhibited excellent properties with 68-fold fluorescence enhancement, a low detection limit (2.46 mu M), a low cytotoxicity, and a good selectivity toward hydrogen sulfide. The success of intracellular imaging indicated that probe 1 could be used in further applications for the investigation of biological functions and pathological roles of H2S in living systems.
引用
收藏
页码：5476 / 5481
页数：6
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