Transcutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model

被引：149

作者：

Yuen, Jonathan M. ^{[2
]}

Shah, Nilam C. ^{[1
]}

Walsh, Joseph T., Jr. ^{[2
]}

Glucksberg, Matthew R. ^{[2
]}

Van Duyne, Richard P. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

来源：

ANALYTICAL CHEMISTRY | 2010年 / 82卷 / 20期

基金：

美国国家科学基金会;

关键词：

IN-VIVO; PARTITION LAYER; BLOOD-GLUCOSE; HUMAN-SKIN; SCATTERING; ACCURACY; STABILITY; PRECISION; TISSUES; SENSOR;

D O I：

10.1021/ac101951j

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

引用

页码：8382 / 8385

页数：4

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