Changes in the content of steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid hormone receptors in the rat brain during the estrous cycle

被引：24

作者：

Camacho-Arroyo, I ^{[1
]}

Neri-Gómez, T ^{[1
]}

González-Arenas, A ^{[1
]}

Guerra-Araiza, C ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2005年 / 94卷 / 1-3期

关键词：

SRC-1; SMRT; estrous cycle; sex steroid receptors; brain; hypothalamus;

D O I：

10.1016/j.jsbmb.2004.12.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, we determined the variations in the content of the steroid receptor coactivator (SRC-1) and the silencing mediator for retinoic acid and thyroid hormone receptors corepressor (SMRT) in the hypothalamus, the preoptic area, and the hippocampus of adult intact rats during the estrous cycle by Western blot. SRC-1 content changed only in the hypothalamus where its lowest content was found on diestrus day with a significant increase at proestrus. This increase was maintained on estrus day. In contrast, SMRT content changed only in the preoptic area where it diminished at metestrus in comparison with the other days of the cycle. SRC-1 content was higher than that of SMRT in the hypothalamus throughout the estrous cycle, whereas SMRT content was higher in the preoptic area. In the hippocampus, there were no significant differences in the content of any cofactor. These results demonstrate that SRC-1 and SMRT content change in a tissue-specific manner in the rat brain during the estrous cycle, and suggest that the transcriptional activity of steroid hormone receptors in the rat brain in physiological conditions is regulated by changes in SRC-1 and SMRT content. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：267 / 272

页数：6

共 28 条

[1] Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice [J].

Apostolakis, EM ;

Ramamurphy, M ;

Zhou, D ;

Oñate, S ;

O'Malley, BW .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (07) :1511-1523

[2] Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior [J].

Auger, AP ;

Tetel, MJ ;

McCarthy, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (13) :7551-7555

[3] Effects of gender and stress on the regulation of steroid receptor coactivator-1 expression in the rat brain and pituitary [J].

Bousios, S ;

Karandrea, D ;

Kittas, C ;

Kitraki, E .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2001, 78 (05) :401-407

[4]

CAMACHOARROYO I, 2003, RECENT RES DEV LIFE, P221

[5] The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding [J].

Giangrande, PH ;

Kimbrel, EA ;

Edwards, DP ;

McDonnell, DP .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (09) :3102-3115

[6]

Glass CK, 2000, GENE DEV, V14, P121

[7] Sexual dimorphism in the content of progesterone and estrogen receptors, and their cofactors in the lung of adult rats [J].

González-Arenas, A ;

Neri-Gómez, T ;

Guerra-Araiza, C ;

Camacho-Arroyo, I .

STEROIDS, 2004, 69 (05) :351-356

[8] Changes in progesterone receptor isoforms content in the rat brain during the oestrous cycle and after oestradiol and progesterone treatments [J].

Guerra-Araiza, C ;

Villamar-Cruz, O ;

González-Arenas, A ;

Chavira, R ;

Camacho-Arroyo, I .

JOURNAL OF NEUROENDOCRINOLOGY, 2003, 15 (10) :984-990

[9] Evidence for expression of estrogen receptor cofactor messenger ribonucleic acid in the ovary and uterus of domesticated animals (sheep, cow and pig) [J].

Hlaing, M ;

Nam, K ;

Lou, J ;

Pope, WF ;

Nephew, KP .

LIFE SCIENCES, 2001, 68 (12) :1427-1438

[10] Nuclear receptor coactivators and corepressors [J].

Horwitz, KB ;

Jackson, TA ;

Rain, DL ;

Richer, JK ;

Takimoto, GS ;

Tung, L .

MOLECULAR ENDOCRINOLOGY, 1996, 10 (10) :1167-1177

← 1 2 3 →