Rapid Carbon-11 Radiolabelling for PET Using Microfluidics

被引：56

作者：

Miller, Philip W. ^{[1
,2
]}

Audrain, Helene ^{[2
]}

Bender, Dirk ^{[2
]}

deMello, Andrew J. ^{[1
]}

Gee, Antony D. ^{[1
,3
]}

Long, Nicholas J. ^{[1
]}

Vilar, Ramon ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus C, Denmark

[3] Kings Coll London, St Thomas Hosp, Div Imaging Sci, London SE1 7EH, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

carbon; microfluidic reactors; positron emission tomography; radiochemistry; radiopharmaceuticals; POSITRON-EMISSION-TOMOGRAPHY; CATALYZED CARBONYLATION; RADIOTRACER SYNTHESIS; COUPLING REACTIONS; CHEMISTRY; MONOXIDE; REACTORS; BRAIN;

D O I：

10.1002/chem.201002644

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Labels all around: A gas-liquid microfluidic reactor is used for the first time to efficiently perform [11C]carbon monoxide carbonylation reactions for the preparation of 11C-radiolabelled amide molecules within a short timeframe (<15 min; see scheme). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：460 / 463

页数：4

共 32 条

[1] Utilisation of [11C]-labelled boron carbonyl complexes in palladium carbonylation reaction [J].

Audrain, H ;

Martarello, L ;

Gee, A ;

Bender, D .

CHEMICAL COMMUNICATIONS, 2004, (05) :558-559

[2] Palladium-Catalyzed Carbonylation-A Reaction Come of Age [J].

Barnard, Christopher F. J. .

ORGANOMETALLICS, 2008, 27 (21) :5402-5422

[3] Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds [J].

Brennfuehrer, Anne ;

Neumann, Helfried ;

Beller, Matthias .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (23) :4114-4133

[4] Control and detection of chemical reactions in microfluidic systems [J].

deMello, Andrew J. .

NATURE, 2006, 442 (7101) :394-402

[5] Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation [J].

Eriksson, Jonas ;

Aberg, Ola ;

Langstrom, Bengt .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 2007 (03) :455-461

[6] Working against time: Rapid radiotracer synthesis and imaging the human brain [J].

Fowler, JS ;

Wolf, AP .

ACCOUNTS OF CHEMICAL RESEARCH, 1997, 30 (04) :181-188

[7]

Fowler JS, 1999, J NUCL MED, V40, p275P

[8]

Günther A, 2006, LAB CHIP, V6, P1487, DOI 10.1039/b609851g

[9] Positron emission tomography in clinical neurology [J].

Herholz, K ;

Heiss, WD .

MOLECULAR IMAGING AND BIOLOGY, 2004, 6 (04) :239-269

[10] A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide [J].

Hostetler, ED ;

Burns, HD .

NUCLEAR MEDICINE AND BIOLOGY, 2002, 29 (08) :845-848

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