Neuroprotective mechanisms of statins in neurodegenerative diseases

被引：0

作者：

Yan, Junqiang ^{[1
]}

Sun, Jiachun ^{[2
]}

Li, Xiangming ^{[3
]}

Zhai, Mingming ^{[1
]}

Jia, Xiaofei ^{[1
]}

机构：

[1] He Nan Univ Sci & Technol, Affiliated Hosp 1, Dept Neurol, Jinghua Rd 24, Luoyang 471003, Henan, Peoples R China

[2] He Nan Univ Sci & Technol, Affiliated Hosp 1, Dept Oncol, Jinghua Rd 24, Luoyang 471003, Henan, Peoples R China

[3] He Nan Univ Sci & Technol, Affiliated Hosp 1, Dept Orthopaed, Jinghua Rd 24, Luoyang 471003, Henan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Statins; vascular dementia; Alzheimer's disease; Parkinson's disease; PLASMA APOLIPOPROTEIN-E; NITRIC-OXIDE SYNTHASE; LOW BLOOD-PRESSURE; ALZHEIMER-DISEASE; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; VASCULAR DEMENTIA; RHO GTPASES; MOUSE MODEL; OXIDATIVE STRESS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Statins can induce neuroprotective effects by various mechanisms, such as by lowering cholesterol levels; decreasing beta-amyloid production, serum apolipoprotein E (APOE) levels, and anti-inflammatory responses; modifying cognition-related receptors, and augmenting endothelial nitric oxide synthase. The use of statins has been related to many neurodegenerative conditions, such as Alzheimer's disease and Parkinson's disease. In our previous review, we discussed the neuroprotective effects of statins by enhancing the levels of endothelial nitric oxide synthase, impairing beta-amyloid production, reducing reactive oxygen species, and modulating cognition-related receptors. The present review discusses the recent finding that statins slow down the progression of these neurodegenerative diseases.

引用

页码：9799 / 9805

页数：7

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