Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c

被引：37

作者：

Lee, Iksoo ^{[1
]}

Kim, JinPyo ^{[1
]}

Ryoo, Inja ^{[2
]}

Kim, YoungHee ^{[2
]}

Choo, SooJin ^{[2
]}

Yoo, IckDong ^{[2
]}

Min, ByungSun ^{[3
]}

Na, MinKyun ^{[4
]}

Hattori, Masao ^{[5
]}

Bae, KiHwan ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305806, South Korea

[3] Catholic Univ Daegu, Coll Pharm, Gyeongbuk 712702, South Korea

[4] Yeungnam Univ, Coll Pharm, Gyeongbuk 712749, South Korea

[5] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 18期

关键词：

Ganoderma lucidum; Lanostane triterpenes; Adipogenesis; SREBP-1c; FAS; ACC; INHIBITORY-ACTIVITY; ADIPOSE CONVERSION; HISTAMINE-RELEASE; OBESITY; ADIPOCYTE; DIFFERENTIATION; CONSTITUENTS; CULTURE;

D O I：

10.1016/j.bmcl.2010.06.093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several lanostane triterpenes [butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4)] bearing a butyl ester side chain from the fruiting bodies of Ganoderma lucidum exhibited considerable inhibitory effects on adipogenesis in 3T3-L1 cells. The inhibitory mechanism of 1 and 3 on adipogenesis in 3T3-L1 cells was investigated; we found that the mRNA and protein expression levels of SREBP-1c were reduced by treatment with 1 and 3 versus the untreated control. Further-more, compounds 1 and 3 suppressed the mRNA expression levels of FAS and ACC. These results demonstrate that inhibition of adipogenesis in 3T3-L1 cells by treatment with 1 and 3 may be mediated in part through down-regulation of the adipogenic transcription factor SREBP-1c and its target genes, such as FAS and ACC. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5577 / 5581

页数：5

共 25 条

[1] REGULATION OF ADIPOCYTE DEVELOPMENT [J].

CORNELIUS, P ;

MACDOUGALD, OA ;

LANE, MD .

ANNUAL REVIEW OF NUTRITION, 1994, 14 :99-129

[2] In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes [J].

El Hadri, K ;

Glorian, M ;

Monsempes, C ;

Dieudonné, MN ;

Pecquery, R ;

Giudicelli, Y ;

Andreani, M ;

Dugail, I ;

Fève, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15130-15141

[3] SPONTANEOUS HERITABLE CHANGES LEADING TO INCREASED ADIPOSE CONVERSION IN 3T3-CELLS [J].

GREEN, H ;

KEHINDE, O .

CELL, 1976, 7 (01) :105-113

[4] ESTABLISHED PRE-ADIPOSE CELL LINE AND ITS DIFFERENTIATION IN CULTURE .2. FACTORS AFFECTING ADIPOSE CONVERSION [J].

GREEN, H ;

KEHINDE, O .

CELL, 1975, 5 (01) :19-27

[5]

Hobbs C., 1995, MED MUSHROOMS EXPLOR

[6] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver [J].

Horton, JD ;

Goldstein, JL ;

Brown, MS .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) :1125-1131

[7] MEDICINAL BENEFITS OF THE MUSHROOM GANODERMA [J].

JONG, SC ;

BIRMINGHAM, JM .

ADVANCES IN APPLIED MICROBIOLOGY, 1992, 37 :101-134

[8]

Kim DH, 1999, BIOL PHARM BULL, V22, P162, DOI 10.1248/bpb.22.162

[9]

KIMURA S, 1988, NUTR SCI VITAM, V34, P433

[10]

KOHDA H, 1985, CHEM PHARM BULL, V33, P1367

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