pH-Responsive Schizophrenic Diblock Copolymers Prepared by Polymerization-Induced Self-Assembly

被引：56

作者：

Canning, Sarah L. ^{[1
]}

Neal, Thomas J. ^{[1
]}

Armes, Steven P. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Dainton Bldg,Brook Hill, Sheffield S3 7HF, S Yorkshire, England

来源：

MACROMOLECULES | 2017年 / 50卷 / 16期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

CROSS-LINKED MICELLES; AQUEOUS DISPERSION POLYMERIZATION; INITIO EMULSION POLYMERIZATION; ZWITTERIONIC BLOCK-COPOLYMERS; PROTECTING GROUP CHEMISTRY; NANO-OBJECTS; RADICAL POLYMERIZATION; AGGREGATION BEHAVIOR; RAFT POLYMERIZATION; DRUG-DELIVERY;

D O I：

10.1021/acs.macromol.7b01005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polymerization-induced self-assembly (PISA) is used for the highly convenient and efficient preparation of ampholytic diblock copolymer nanoparticles directly in acidic aqueous solution. Cationic nanoparticles comprising a protonated polyamine stabilizer block and a hydrophobic polyacid core-forming block are formed at pH 2. Micelle inversion occurs at pH 10 to produce anionic nanoparticles with an ionized polyacid stabilizer block and a hydrophobic polyamine core-forming block. Macroscopic precipitation occurs at around pH 6-7, which lies close to the isoelectric point of this ampholytic diblock copolymer. Incorporation of fluorescein and rhodamine dye labels into the acid and amine blocks, respectively, leads to dual-color bifluorescent self-reporting pH-responsive nanoparticles.

引用

页码：6108 / 6116

页数：9

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